Product Information
Molecular Weight60002Da
Protein Name5' exonuclease Apollo
Human Gene Id64858
Human Swiss Prot NoQ9H816
Mouse Swiss Prot NoQ8C7W7
SpecificitySNM1B Polyclonal Antibody detects endogenous levels of SNM1B protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameDCLRE1B; SNM1B; 5' exonuclease Apollo; DNA cross-link repair 1B protein; SNM1 homolog B; SNMIB; hSNM1B
Observed Band(KD)60
Functionfunction:May be required for DNA interstrand cross-link repair.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.,subcellular location:Localizes to discrete foci.,
Subcellular LocationChromosome, telomere. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.
ExpressionPlacenta,Retinoblastoma,Teratocarcinoma,
BackgroundDNA cross-link repair 1B(DCLRE1B) Homo sapiens DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000 [PubMed 10848582]).[supplied by OMIM, Mar 2008],