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Cell Signal Transduction Research Antibodies
ABCG1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight75592Da
Protein NameATP-binding cassette sub-family G member 1
Human Gene Id9619
Human Swiss Prot NoP45844
Mouse Gene Id11307
Mouse Swiss Prot NoQ64343
SpecificityABCG1 Polyclonal Antibody detects endogenous levels of ABCG1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameABCG1; ABC8; WHT1; ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog
Observed Band(KD)75
Functionalternative products:Additional isoforms seem to exist,disease:Overexpressed in macrophages from patients with Tangier disease compared to control macrophages. Expressed in foamy macrophages within the atherosclerotic plaque. May play a role in the cholesterol metabolism of macrophages in vitro and in the atherosclerotic plaque.,function:Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.,induction:Strongly induced in monocyte-derived macrophages during cholesterol influx. Conversely, mRNA and protein expression are suppressed by lipid efflux. Induction is mediated by the liver X receptor/retinoid X receptor (LXR/RXR) pathway. Not induced by bacterial lipopolysaccharides (LPS). Repress
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell membrane . Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
ExpressionExpressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from ABCG1 . at AA range: 560-640
Gene NameABCG1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/10000. Not yet tested in other applications.
BackgroundATP binding cassette subfamily G member 1(ABCG1) Homo sapiens The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75060-Conjugate. Price: $485 / Size: 100μl.
E20-75060-FITC$485 / 100μlE20-75060-Biotin$485 / 100μlE20-75060-HRP$485 / 100μlE20-75060-AP$485 / 100μlE20-75060-AF350$485 / 100μlE20-75060-AF405M$485 / 100μlE20-75060-AF488$485 / 100μlE20-75060-AF514$485 / 100μlE20-75060-AF532$485 / 100μlE20-75060-AF555$485 / 100μlE20-75060-AF568$485 / 100μlE20-75060-AF405S$485 / 100μlE20-75060-AF405L$485 / 100μlE20-75060-AF546$485 / 100μlE20-75060-AF594$485 / 100μlE20-75060-AF610$485 / 100μlE20-75060-AF635$485 / 100μlE20-75060-AF647$485 / 100μlE20-75060-AF680$485 / 100μlE20-75060-AF700$485 / 100μlE20-75060-AF750$485 / 100μlE20-75060-AF790$485 / 100μlE20-75060-APC$485 / 100μlE20-75060-PE$485 / 100μlE20-75060-Cy3$485 / 100μlE20-75060-Cy5$485 / 100μlE20-75060-Cy5.5$485 / 100μlE20-75060-Cy7$485 / 100μlE20-75060-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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