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Cell Signal Transduction Research Antibodies
APLP-1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight72176Da
Protein NameAmyloid-like protein 1
Human Gene Id333
Human Swiss Prot NoP51693
Mouse Gene Id11803
Mouse Swiss Prot NoQ03157
SpecificityAPLP-1 Polyclonal Antibody detects endogenous levels of APLP-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameAPLP1; Amyloid-like protein 1; APLP; APLP-1
Observed Band(KD)72
Functiondomain:The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis.,function:May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.,function:The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.,miscellaneous:Binds zinc and copper in the extracellular domain. Zinc-
Subcellular LocationCell membrane; Single-pass type I membrane protein.; [C30]: Cytoplasm. C-terminally processed in the Golgi complex.
ExpressionExpressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from APLP-1 . at AA range: 360-440
Gene NameAPLP1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/10000. Not yet tested in other applications.
Backgroundamyloid beta precursor like protein 1(APLP1) Homo sapiens This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75058-Conjugate. Price: $485 / Size: 100μl.
E20-75058-FITC$485 / 100μlE20-75058-Biotin$485 / 100μlE20-75058-HRP$485 / 100μlE20-75058-AP$485 / 100μlE20-75058-AF350$485 / 100μlE20-75058-AF405M$485 / 100μlE20-75058-AF488$485 / 100μlE20-75058-AF514$485 / 100μlE20-75058-AF532$485 / 100μlE20-75058-AF555$485 / 100μlE20-75058-AF568$485 / 100μlE20-75058-AF405S$485 / 100μlE20-75058-AF405L$485 / 100μlE20-75058-AF546$485 / 100μlE20-75058-AF594$485 / 100μlE20-75058-AF610$485 / 100μlE20-75058-AF635$485 / 100μlE20-75058-AF647$485 / 100μlE20-75058-AF680$485 / 100μlE20-75058-AF700$485 / 100μlE20-75058-AF750$485 / 100μlE20-75058-AF790$485 / 100μlE20-75058-APC$485 / 100μlE20-75058-PE$485 / 100μlE20-75058-Cy3$485 / 100μlE20-75058-Cy5$485 / 100μlE20-75058-Cy5.5$485 / 100μlE20-75058-Cy7$485 / 100μlE20-75058-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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