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Cell Signal Transduction Research Antibodies
α-SMA Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight42009Da
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.05% sodium azide.
Protein NameActin aortic smooth muscle
Human Gene Id59
Human Swiss Prot NoP62736
Mouse Gene Id11475
Mouse Swiss Prot NoP62737
Rat Gene Id81633
Rat Swiss Prot NoP62738
Specificityα-SMA Polyclonal Antibody detects endogenous levels of α-SMA protein.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameACTA2; ACTSA; ACTVS; GIG46; Actin; aortic smooth muscle; Alpha-actin-2; Cell growth-inhibiting gene 46 protein
Observed Band(KD)42
Functiondisease:Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actin
Subcellular LocationCytoplasm, cytoskeleton.
ExpressionPituitary,Uterus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from the N-terminal region of human α-SMA.
Gene NameACTA2
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Backgroundactin, alpha 2, smooth muscle, aorta(ACTA2) Homo sapiens The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75053-Conjugate. Price: $485 / Size: 100μl.
E20-75053-FITC$485 / 100μlE20-75053-Biotin$485 / 100μlE20-75053-HRP$485 / 100μlE20-75053-AP$485 / 100μlE20-75053-AF350$485 / 100μlE20-75053-AF405M$485 / 100μlE20-75053-AF488$485 / 100μlE20-75053-AF514$485 / 100μlE20-75053-AF532$485 / 100μlE20-75053-AF555$485 / 100μlE20-75053-AF568$485 / 100μlE20-75053-AF405S$485 / 100μlE20-75053-AF405L$485 / 100μlE20-75053-AF546$485 / 100μlE20-75053-AF594$485 / 100μlE20-75053-AF610$485 / 100μlE20-75053-AF635$485 / 100μlE20-75053-AF647$485 / 100μlE20-75053-AF680$485 / 100μlE20-75053-AF700$485 / 100μlE20-75053-AF750$485 / 100μlE20-75053-AF790$485 / 100μlE20-75053-APC$485 / 100μlE20-75053-PE$485 / 100μlE20-75053-Cy3$485 / 100μlE20-75053-Cy5$485 / 100μlE20-75053-Cy5.5$485 / 100μlE20-75053-Cy7$485 / 100μlE20-75053-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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