Product Information
Molecular Weight95051Da
Protein NameNuclear valosin-containing protein-like
Human Gene Id4931
Human Swiss Prot NoO15381
Mouse Gene Id67459
Mouse Swiss Prot NoQ9DBY8
SpecificityNVL Polyclonal Antibody detects endogenous levels of NVL protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNVL; Nuclear valosin-containing protein-like; NVLp; Nuclear VCP-like protein
Observed Band(KD)95
FunctionPTM:Phosphorylated.,similarity:Belongs to the AAA ATPase family.,tissue specificity:Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.,
Subcellular Location[Isoform 2]: Nucleus, nucleoplasm .; [Isoform 1]: Nucleus, nucleolus . Nucleus, nucleoplasm . Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus. .
ExpressionWidely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
Backgroundnuclear VCP-like(NVL) Homo sapiens This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011],