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Cell Signal Transduction Research Antibodies
DFNA5 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight54555Da
Protein NameNon-syndromic hearing impairment protein 5
Human Gene Id1687
Human Swiss Prot NoO60443
Mouse Swiss Prot NoQ9Z2D3
SpecificityDFNA5 Polyclonal Antibody detects endogenous levels of DFNA5 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameDFNA5; ICERE1; Non-syndromic hearing impairment protein 5; Inversely correlated with estrogen receptor expression 1; ICERE-1
Observed Band(KD)54
Functiondisease:Defects in DFNA5 are the cause of non-syndromic sensorineural deafness autosomal dominant type 5 (DFNA5) [MIM:600994]. DFNA5 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,similarity:Belongs to the gasdermin family.,tissue specificity:Expressed in cochlea. Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta.,
Subcellular Location[Gasdermin-E, N-terminal]: Cell membrane ; Multi-pass membrane protein .; [Gasdermin-E]: Cytoplasm, cytosol .
ExpressionExpressed in cochlea (PubMed:9771715). Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta (PubMed:9771715).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from DFNA5 . at AA range: 200-280
Gene NameDFNA5
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
BackgroundDFNA5, deafness associated tumor suppressor(DFNA5) Homo sapiens Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75046-Conjugate. Price: $485 / Size: 100μl.
E20-75046-FITC$485 / 100μlE20-75046-Biotin$485 / 100μlE20-75046-HRP$485 / 100μlE20-75046-AP$485 / 100μlE20-75046-AF350$485 / 100μlE20-75046-AF405M$485 / 100μlE20-75046-AF488$485 / 100μlE20-75046-AF514$485 / 100μlE20-75046-AF532$485 / 100μlE20-75046-AF555$485 / 100μlE20-75046-AF568$485 / 100μlE20-75046-AF405S$485 / 100μlE20-75046-AF405L$485 / 100μlE20-75046-AF546$485 / 100μlE20-75046-AF594$485 / 100μlE20-75046-AF610$485 / 100μlE20-75046-AF635$485 / 100μlE20-75046-AF647$485 / 100μlE20-75046-AF680$485 / 100μlE20-75046-AF700$485 / 100μlE20-75046-AF750$485 / 100μlE20-75046-AF790$485 / 100μlE20-75046-APC$485 / 100μlE20-75046-PE$485 / 100μlE20-75046-Cy3$485 / 100μlE20-75046-Cy5$485 / 100μlE20-75046-Cy5.5$485 / 100μlE20-75046-Cy7$485 / 100μlE20-75046-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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