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Cell Signal Transduction Research Antibodies
NPAS2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight91761Da
Protein NameNeuronal PAS domain-containing protein 2
Human Gene Id4862
Human Swiss Prot NoQ99743
Mouse Swiss Prot NoP97460
SpecificityNPAS2 Polyclonal Antibody detects endogenous levels of NPAS2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNPAS2; BHLHE9; MOP4; PASD4; Neuronal PAS domain-containing protein 2; Neuronal PAS2; Basic-helix-loop-helix-PAS protein MOP4; Class E basic helix-loop-helix protein 9; bHLHe9; Member of PAS protein 4; PAS domain-containing protein 4
Observed Band(KD)91
Functionfunction:BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.,polymorphism:Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIM:608516]. SAD is a depressive condition resulting from seasonal changes, and with diurnal preference.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent t
Subcellular LocationNucleus .
ExpressionHuman lung,Lung,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from NPAS2 . at AA range: 340-420
Gene NameNPAS2
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Backgroundneuronal PAS domain protein 2(NPAS2) Homo sapiens The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75045-Conjugate. Price: $485 / Size: 100μl.
E20-75045-FITC$485 / 100μlE20-75045-Biotin$485 / 100μlE20-75045-HRP$485 / 100μlE20-75045-AP$485 / 100μlE20-75045-AF350$485 / 100μlE20-75045-AF405M$485 / 100μlE20-75045-AF488$485 / 100μlE20-75045-AF514$485 / 100μlE20-75045-AF532$485 / 100μlE20-75045-AF555$485 / 100μlE20-75045-AF568$485 / 100μlE20-75045-AF405S$485 / 100μlE20-75045-AF405L$485 / 100μlE20-75045-AF546$485 / 100μlE20-75045-AF594$485 / 100μlE20-75045-AF610$485 / 100μlE20-75045-AF635$485 / 100μlE20-75045-AF647$485 / 100μlE20-75045-AF680$485 / 100μlE20-75045-AF700$485 / 100μlE20-75045-AF750$485 / 100μlE20-75045-AF790$485 / 100μlE20-75045-APC$485 / 100μlE20-75045-PE$485 / 100μlE20-75045-Cy3$485 / 100μlE20-75045-Cy5$485 / 100μlE20-75045-Cy5.5$485 / 100μlE20-75045-Cy7$485 / 100μlE20-75045-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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