World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
TRPV4 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight98281Da
Protein NameTransient receptor potential cation channel subfamily V member 4
Human Gene Id59341
Human Swiss Prot NoQ9HBA0
Mouse Gene Id63873
Mouse Swiss Prot NoQ9EPK8
Rat Gene Id66026
Rat Swiss Prot NoQ9ERZ8
SpecificityTRPV4 Polyclonal Antibody detects endogenous levels of TRPV4 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTRPV4; VRL2; VROAC; Transient receptor potential cation channel subfamily V member 4; TrpV4; Osm-9-like TRP channel 4; OTRPC4; Transient receptor potential protein 12; TRP12;Vanilloid receptor-like channel 2; Vanilloid receptor-like protein 2; VRL-2; Vanilloid receptor-related osmotically-activated channel; VR-OAC
Observed Band(KD)98
Functiondisease:Defects in TRPV4 are the cause of brachyolmia type 3 [MIM:113500]; also called brachyrachia. The brachyolmias constitute a clinically and genetically heterogeneous group of skeletal dysplasias characterized by a short trunk, scoliosis and mild short stature. Type 3 brachyolmia is an autosomal dominant form with severe kyphoscoliosis and flattened, irregular cervical vertebrae.,function:Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism.,similarity:Belongs to the transient receptor family. TrpV subfamily
Subcellular LocationCell membrane . Apical cell membrane ; Multi-pass membrane protein . Cell junction, adherens junction . Cell projection, cilium . Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. .; [Isoform 1]: Cell membrane .; [Isoform 5]: Cell membrane .; [Isoform 2]: Endoplasmic reticulum .; [Isoform 4]: Endoplasmic reticulum .; [Isoform 6]: Endoplasmic reticulum .
ExpressionFound in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human TRPV4. AA range:417-466
Gene NameTRPV4
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundtransient receptor potential cation channel subfamily V member 4(TRPV4) Homo sapiens This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-75040-Conjugate. Price: $485 / Size: 100μl.
E20-75040-FITC$485 / 100μlE20-75040-Biotin$485 / 100μlE20-75040-HRP$485 / 100μlE20-75040-AP$485 / 100μlE20-75040-AF350$485 / 100μlE20-75040-AF405M$485 / 100μlE20-75040-AF488$485 / 100μlE20-75040-AF514$485 / 100μlE20-75040-AF532$485 / 100μlE20-75040-AF555$485 / 100μlE20-75040-AF568$485 / 100μlE20-75040-AF405S$485 / 100μlE20-75040-AF405L$485 / 100μlE20-75040-AF546$485 / 100μlE20-75040-AF594$485 / 100μlE20-75040-AF610$485 / 100μlE20-75040-AF635$485 / 100μlE20-75040-AF647$485 / 100μlE20-75040-AF680$485 / 100μlE20-75040-AF700$485 / 100μlE20-75040-AF750$485 / 100μlE20-75040-AF790$485 / 100μlE20-75040-APC$485 / 100μlE20-75040-PE$485 / 100μlE20-75040-Cy3$485 / 100μlE20-75040-Cy5$485 / 100μlE20-75040-Cy5.5$485 / 100μlE20-75040-Cy7$485 / 100μlE20-75040-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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