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Cell Signal Transduction Research Antibodies
ING4 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight28530Da
Protein NameInhibitor of growth protein 4
Human Gene Id51147
Human Swiss Prot NoQ9UNL4
Mouse Gene Id28019
Mouse Swiss Prot NoQ8C0D7
SpecificityING4 Polyclonal Antibody detects endogenous levels of ING4 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameING4; My036; Inhibitor of growth protein 4; p29ING4
Observed Band(KD)28
Functionfunction:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).,similarity:Belongs to the ING family.,similarity:Contains 1 PHD-type zinc finger.,subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, E
Subcellular LocationNucleus .
ExpressionB-cell,Epithelium,Fetal brain,Lung,Pituitary,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human ING4. AA range:107-156
Gene NameING4
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundinhibitor of growth family member 4(ING4) Homo sapiens This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75037-Conjugate. Price: $485 / Size: 100μl.
E20-75037-FITC$485 / 100μlE20-75037-Biotin$485 / 100μlE20-75037-HRP$485 / 100μlE20-75037-AP$485 / 100μlE20-75037-AF350$485 / 100μlE20-75037-AF405M$485 / 100μlE20-75037-AF488$485 / 100μlE20-75037-AF514$485 / 100μlE20-75037-AF532$485 / 100μlE20-75037-AF555$485 / 100μlE20-75037-AF568$485 / 100μlE20-75037-AF405S$485 / 100μlE20-75037-AF405L$485 / 100μlE20-75037-AF546$485 / 100μlE20-75037-AF594$485 / 100μlE20-75037-AF610$485 / 100μlE20-75037-AF635$485 / 100μlE20-75037-AF647$485 / 100μlE20-75037-AF680$485 / 100μlE20-75037-AF700$485 / 100μlE20-75037-AF750$485 / 100μlE20-75037-AF790$485 / 100μlE20-75037-APC$485 / 100μlE20-75037-PE$485 / 100μlE20-75037-Cy3$485 / 100μlE20-75037-Cy5$485 / 100μlE20-75037-Cy5.5$485 / 100μlE20-75037-Cy7$485 / 100μlE20-75037-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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