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Cell Signal Transduction Research Antibodies
FTO Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight58282Da
Protein NameAlpha-ketoglutarate-dependent dioxygenase FTO
Human Gene Id79068
Human Swiss Prot NoQ9C0B1
Mouse Gene Id26383
Mouse Swiss Prot NoQ8BGW1
Rat Gene Id291905
Rat Swiss Prot NoQ2A121
SpecificityFTO Polyclonal Antibody detects endogenous levels of FTO protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameFTO; KIAA1752; Alpha-ketoglutarate-dependent dioxygenase FTO; Fat mass and obesity-associated protein
Observed Band(KD)58
Functionfunction:The precise function of this protein remains to be determined.,polymorphism:At least one intronic variation within the gene predisposes to childhood and adult obesity.,similarity:Belongs to the fto family.,tissue specificity:Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.,
Subcellular LocationNucleus . Nucleus speckle . Cytoplasm . Localizes mainly in the nucleus, where it is able to demethylate N(6)-methyladenosine (m6A) and N(6),2'-O-dimethyladenosine cap (m6A(m)) in U6 small nuclear RNA (snRNA), N(1)-methyladenine from tRNAs and internal m6A in mRNAs (PubMed:30197295). In the cytoplasm, mediates demethylation of m6A and m6A(m) in mRNAs and N(1)-methyladenine from tRNAs (PubMed:30197295). .
ExpressionUbiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary (PubMed:17434869, PubMed:17496892). Highly expressed in highly expressed in acute myeloid leukemias (AML) with t(11;11)(q23;23) with KMT2A/MLL1 rearrangements, t(15;17)(q21;q21)/PML-RARA, FLT3-ITD, and/or NPM1 mutations (PubMed:28017614).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human FTO. AA range:19-68
Gene NameFTO
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
BackgroundFTO, alpha-ketoglutarate dependent dioxygenase(FTO) Homo sapiens This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75033-Conjugate. Price: $485 / Size: 100μl.
E20-75033-FITC$485 / 100μlE20-75033-Biotin$485 / 100μlE20-75033-HRP$485 / 100μlE20-75033-AP$485 / 100μlE20-75033-AF350$485 / 100μlE20-75033-AF405M$485 / 100μlE20-75033-AF488$485 / 100μlE20-75033-AF514$485 / 100μlE20-75033-AF532$485 / 100μlE20-75033-AF555$485 / 100μlE20-75033-AF568$485 / 100μlE20-75033-AF405S$485 / 100μlE20-75033-AF405L$485 / 100μlE20-75033-AF546$485 / 100μlE20-75033-AF594$485 / 100μlE20-75033-AF610$485 / 100μlE20-75033-AF635$485 / 100μlE20-75033-AF647$485 / 100μlE20-75033-AF680$485 / 100μlE20-75033-AF700$485 / 100μlE20-75033-AF750$485 / 100μlE20-75033-AF790$485 / 100μlE20-75033-APC$485 / 100μlE20-75033-PE$485 / 100μlE20-75033-Cy3$485 / 100μlE20-75033-Cy5$485 / 100μlE20-75033-Cy5.5$485 / 100μlE20-75033-Cy7$485 / 100μlE20-75033-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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