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Cell Signal Transduction Research Antibodies
Elmo1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight83829Da
Protein NameEngulfment and cell motility protein 1
Human Gene Id9844
Human Swiss Prot NoQ92556
Mouse Gene Id140580
Mouse Swiss Prot NoQ8BPU7
SpecificityElmo1 Polyclonal Antibody detects endogenous levels of Elmo1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameELMO1; KIAA0281; Engulfment and cell motility protein 1; Protein ced-12 homolog
Observed Band(KD)83
Functionfunction:Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.,PTM:Phosphorylated by HCK.,similarity:Contains 1 ELMO domain.,similarity:Contains 1 PH domain.,subcellular location:Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.,subunit:Interacts with BAI1 (By similarity). Interacts directly with the SH3-domain of DOCK1 via its SH3-binding site. Part of a complex with DOCK1 and RAC1. Part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with PLEKHG6.,tissue specificity:Widely expressed, with a higher expression in the spleen and placenta.,
Subcellular LocationCytoplasm. Cell membrane. Translocation to plasma membrane seems to be mediated by DOCK1 and CRK.
ExpressionWidely expressed, with a higher expression in the spleen and placenta.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Elmo1. AA range:22-71
Gene NameELMO1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundengulfment and cell motility 1(ELMO1) Homo sapiens This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
Conjugated Antibody
This product is also available conjugated. Format: E20-75030-Conjugate. Price: $485 / Size: 100μl.
E20-75030-FITC$485 / 100μlE20-75030-Biotin$485 / 100μlE20-75030-HRP$485 / 100μlE20-75030-AP$485 / 100μlE20-75030-AF350$485 / 100μlE20-75030-AF405M$485 / 100μlE20-75030-AF488$485 / 100μlE20-75030-AF514$485 / 100μlE20-75030-AF532$485 / 100μlE20-75030-AF555$485 / 100μlE20-75030-AF568$485 / 100μlE20-75030-AF405S$485 / 100μlE20-75030-AF405L$485 / 100μlE20-75030-AF546$485 / 100μlE20-75030-AF594$485 / 100μlE20-75030-AF610$485 / 100μlE20-75030-AF635$485 / 100μlE20-75030-AF647$485 / 100μlE20-75030-AF680$485 / 100μlE20-75030-AF700$485 / 100μlE20-75030-AF750$485 / 100μlE20-75030-AF790$485 / 100μlE20-75030-APC$485 / 100μlE20-75030-PE$485 / 100μlE20-75030-Cy3$485 / 100μlE20-75030-Cy5$485 / 100μlE20-75030-Cy5.5$485 / 100μlE20-75030-Cy7$485 / 100μlE20-75030-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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