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Cell Signal Transduction Research Antibodies
Ihh Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight45251Da
Protein NameIndian hedgehog protein
Human Gene Id3549
Human Swiss Prot NoQ14623
Mouse Gene Id16147
Mouse Swiss Prot NoP97812
SpecificityIhh Polyclonal Antibody detects endogenous levels of Ihh protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIHH; Indian hedgehog protein; IHH; HHG-2
Observed Band(KD)45
Functiondisease:Defects in IHH are a cause of acrocapitofemoral dysplasia (ACFD) [MIM:607778]. ACFD is a disorder characterized by short stature of variable severity with postnatal onset. The most constant radiographic abnormalities are observed in the tubular bones of the hands and in the proximal part of the femur. Cone-shaped epiphyses or a similar epiphyseal configuration with premature epimetaphyseal fusion result in shortening of the skeletal components involved. Cone-shaped epiphyses were also present to a variable extent at the shoulders, knees, and ankles.,disease:Defects in IHH are the cause of brachydactyly type A1 (BDA1) [MIM:112500]. BDA1 is an autosomal dominant disorder characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short.,function:Intercellular signal essential for a varie
Subcellular Location[Indian hedgehog protein N-product]: Cell membrane ; Lipid-anchor ; Extracellular side . The N-terminal peptide remains associated with the cell surface. .; [Indian hedgehog protein C-product]: Secreted, extracellular space . The C-terminal peptide diffuses from the cell. .; Cell membrane .
ExpressionExpressed in embryonic lung, and in adult kidney and liver.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Ihh. AA range:209-258
Gene NameIHH
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundindian hedgehog(IHH) Homo sapiens This gene encodes a member of the hedgehog family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, including an N-terminal fragment that is involved in signaling. Hedgehog family proteins are essential secreted signaling molecules that regulate a variety of developmental processes including growth, patterning and morphogenesis. The protein encoded by this gene specifically plays a role in bone growth and differentiation. Mutations in this gene are the cause of brachydactyly type A1, which is characterized by shortening or malformation of the fingers and toes. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Nov 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75023-Conjugate. Price: $485 / Size: 100μl.
E20-75023-FITC$485 / 100μlE20-75023-Biotin$485 / 100μlE20-75023-HRP$485 / 100μlE20-75023-AP$485 / 100μlE20-75023-AF350$485 / 100μlE20-75023-AF405M$485 / 100μlE20-75023-AF488$485 / 100μlE20-75023-AF514$485 / 100μlE20-75023-AF532$485 / 100μlE20-75023-AF555$485 / 100μlE20-75023-AF568$485 / 100μlE20-75023-AF405S$485 / 100μlE20-75023-AF405L$485 / 100μlE20-75023-AF546$485 / 100μlE20-75023-AF594$485 / 100μlE20-75023-AF610$485 / 100μlE20-75023-AF635$485 / 100μlE20-75023-AF647$485 / 100μlE20-75023-AF680$485 / 100μlE20-75023-AF700$485 / 100μlE20-75023-AF750$485 / 100μlE20-75023-AF790$485 / 100μlE20-75023-APC$485 / 100μlE20-75023-PE$485 / 100μlE20-75023-Cy3$485 / 100μlE20-75023-Cy5$485 / 100μlE20-75023-Cy5.5$485 / 100μlE20-75023-Cy7$485 / 100μlE20-75023-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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