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Cell Signal Transduction Research Antibodies
DDR1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight101128Da
Protein NameEpithelial discoidin domain-containing receptor 1
Human Gene Id780
Human Swiss Prot NoQ08345
Mouse Gene Id12305
Mouse Swiss Prot NoQ03146
Rat Swiss Prot NoQ63474
SpecificityDDR1 Polyclonal Antibody detects endogenous levels of DDR1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameDDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; Epithelial discoidin domain-containing receptor 1; Epithelial discoidin domain receptor 1; CD167 antigen-like family member A; Cell adhesion kinase; Discoidin receptor tyrosine kinase; HGK2;
Observed Band(KD)100
Functioncatalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:The Gly/Pro-rich domains may be required for an unusual geometry of interaction with ligand or substrates.,function:May be involved in cell-cell interactions and recognition.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 F5/8 type C domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed at low levels in most adult tissues and is highest in the brain and lung. Abundant in breast carcinoma cell lines.,
Subcellular Location[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted .; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
ExpressionDetected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the brain, lung, placenta and kidney. Lower levels of expression are detected in melanocytes, heart, liver, skeletal muscle and pancreas. Abundant in breast carcinoma cell lines. In the colonic mucosa, expressed in epithelia but not in the connective tissue of the lamina propria. In the thyroid gland, expressed in the epithelium of the thyroid follicles. In pancreas, expressed in the islets of Langerhans cells, but not in the surrounding epithelial cells of the exocrine pancreas. In kidney, expressed in the epithelia of the distal tubules. Not
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from DDR1 . at AA range: 740-820
Gene NameDDR1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgrounddiscoidin domain receptor tyrosine kinase 1(DDR1) Homo sapiens Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75015-Conjugate. Price: $485 / Size: 100μl.
E20-75015-FITC$485 / 100μlE20-75015-Biotin$485 / 100μlE20-75015-HRP$485 / 100μlE20-75015-AP$485 / 100μlE20-75015-AF350$485 / 100μlE20-75015-AF405M$485 / 100μlE20-75015-AF488$485 / 100μlE20-75015-AF514$485 / 100μlE20-75015-AF532$485 / 100μlE20-75015-AF555$485 / 100μlE20-75015-AF568$485 / 100μlE20-75015-AF405S$485 / 100μlE20-75015-AF405L$485 / 100μlE20-75015-AF546$485 / 100μlE20-75015-AF594$485 / 100μlE20-75015-AF610$485 / 100μlE20-75015-AF635$485 / 100μlE20-75015-AF647$485 / 100μlE20-75015-AF680$485 / 100μlE20-75015-AF700$485 / 100μlE20-75015-AF750$485 / 100μlE20-75015-AF790$485 / 100μlE20-75015-APC$485 / 100μlE20-75015-PE$485 / 100μlE20-75015-Cy3$485 / 100μlE20-75015-Cy5$485 / 100μlE20-75015-Cy5.5$485 / 100μlE20-75015-Cy7$485 / 100μlE20-75015-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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