PDGFR-β Polyclonal Antibody

Name: PDGFR-β Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75011
Price: 225 USD
Availability: InStock

E20-75011Cite ID: EN0055144Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight123968Da

Protein NamePlatelet-derived growth factor receptor beta

Human Gene Id5159

Human Swiss Prot NoP09619

Mouse Swiss Prot NoP05622

Rat Gene Id24629

Rat Swiss Prot NoQ05030

SpecificityPDGFR-β Polyclonal Antibody detects endogenous levels of PDGFR-β protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NamePDGFRB; PDGFR; PDGFR1; Platelet-derived growth factor receptor beta; PDGF-R-beta; PDGFR-beta; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; Platelet-deri

Observed Band(KD)125

Functioncatalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving PDGFRB is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with ETV6 on chromosome 12 creating an PDGFRB-ETV6 fusion protein.,disease:A chromosomal aberration involving PDGFRB is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with EVT6/TEL. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).,disease:A chromosomal aberration involving PDGFRB may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with TRIP11. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.,disease:A chromosomal aberration involving PDGFRB may be a cause

Subcellular LocationCell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle. Lysosome lumen. After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation.

ExpressionBrain,Spleen,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from PDGFR-β . at AA range: 710-790

Gene NamePDGFRB

DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.

Backgroundplatelet derived growth factor receptor beta(PDGFRB) Homo sapiens This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75011-Conjugate. Price: $485 / Size: 100μl.

E20-75011-FITC$485 / 100μlE20-75011-Biotin$485 / 100μlE20-75011-HRP$485 / 100μlE20-75011-AP$485 / 100μlE20-75011-AF350$485 / 100μlE20-75011-AF405M$485 / 100μlE20-75011-AF488$485 / 100μlE20-75011-AF514$485 / 100μlE20-75011-AF532$485 / 100μlE20-75011-AF555$485 / 100μlE20-75011-AF568$485 / 100μlE20-75011-AF405S$485 / 100μlE20-75011-AF405L$485 / 100μlE20-75011-AF546$485 / 100μlE20-75011-AF594$485 / 100μlE20-75011-AF610$485 / 100μlE20-75011-AF635$485 / 100μlE20-75011-AF647$485 / 100μlE20-75011-AF680$485 / 100μlE20-75011-AF700$485 / 100μlE20-75011-AF750$485 / 100μlE20-75011-AF790$485 / 100μlE20-75011-APC$485 / 100μlE20-75011-PE$485 / 100μlE20-75011-Cy3$485 / 100μlE20-75011-Cy5$485 / 100μlE20-75011-Cy5.5$485 / 100μlE20-75011-Cy7$485 / 100μlE20-75011-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.