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ZnT-8 Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-74990

  • Amount:

    100ul

  • Reactivity:

    Human,Mouse,Rat

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen..

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human SLC30A8. AA range:171-220

  • Source:

    Polyclonal, Rabbit

  • Western blot analysis of the lysates from HeLa cells using SLC30A8 antibody.

  • Gene Name:

    SLC30A8

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Zinc transporter 8

  • Human Gene Id:

    169026

  • Human Swiss Prot No:

    Q8IWU4

  • Specificity:

    ZnT-8 Polyclonal Antibody detects endogenous levels of ZnT-8 protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    SLC30A8; ZNT8; Zinc transporter 8; ZnT-8; Solute carrier family 30 member 8MolecularWeight: 40729Da

  • Observed Band(KD):

    41

  • Background:

    solute carrier family 30 member 8(SLC30A8) Homo sapiens The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010],

  • Function:

    domain:Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.,function:Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.,polymorphism:Variant Trp-325 is a risk factor that confers susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM) [MIM:125853].,similarity:Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.,subcellular location:Strictly associated with the insulin granule secretory.,tissue specificity:Strictly restricted to the pancreas islets cells. Found in insulin-producing beta cells and colocalized with insulin.,

  • Subcellular Location:

    cell,Golgi apparatus,plasma membrane,integral component of membrane,cytoplasmic, membrane-bounded vesicle,secretory granule,transport vesicle membrane,secretory granule membrane,cytoplasmic vesicle,

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