Product Information
Molecular Weight50819Da
Protein NameZinc finger protein PLAGL1
Human Gene Id5325
Human Swiss Prot NoQ9UM63
SpecificityZAC1 Polyclonal Antibody detects endogenous levels of ZAC1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePLAGL1; LOT1; ZAC; Zinc finger protein PLAGL1; Lost on transformation 1; LOT-1; Pleiomorphic adenoma-like protein 1; Tumor supressor ZAC
Observed Band(KD)50
Functionfunction:Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 7 C2H2-type zinc fingers.,
Subcellular LocationNucleus .
ExpressionColon,Fetal kidney,Lung,Mammary gland,Pituitary,Placenta,
BackgroundPLAG1 like zinc finger 1(PLAGL1) Homo sapiens This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015],