World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
YAP Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight48755Da
Protein NameYorkie homolog
Human Gene Id10413
Human Swiss Prot NoP46937
Mouse Gene Id22601
Mouse Swiss Prot NoP46938
Rat Gene Id363014
Rat Swiss Prot NoQ2EJA0
SpecificityYAP Polyclonal Antibody detects endogenous levels of YAP protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameYAP1; YAP65; Yorkie homolog; 65 kDa Yes-associated protein; YAP65
Observed Band(KD)67
FunctionPTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif.,
Subcellular LocationCytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
ExpressionIncreased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human YAP. AA range:281-330
Gene NameYAP1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
BackgroundYes associated protein 1(YAP1) Homo sapiens This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],
Conjugated Antibody
This product is also available conjugated. Format: E20-74924-Conjugate. Price: $485 / Size: 100μl.
E20-74924-FITC$485 / 100μlE20-74924-Biotin$485 / 100μlE20-74924-HRP$485 / 100μlE20-74924-AP$485 / 100μlE20-74924-AF350$485 / 100μlE20-74924-AF405M$485 / 100μlE20-74924-AF488$485 / 100μlE20-74924-AF514$485 / 100μlE20-74924-AF532$485 / 100μlE20-74924-AF555$485 / 100μlE20-74924-AF568$485 / 100μlE20-74924-AF405S$485 / 100μlE20-74924-AF405L$485 / 100μlE20-74924-AF546$485 / 100μlE20-74924-AF594$485 / 100μlE20-74924-AF610$485 / 100μlE20-74924-AF635$485 / 100μlE20-74924-AF647$485 / 100μlE20-74924-AF680$485 / 100μlE20-74924-AF700$485 / 100μlE20-74924-AF750$485 / 100μlE20-74924-AF790$485 / 100μlE20-74924-APC$485 / 100μlE20-74924-PE$485 / 100μlE20-74924-Cy3$485 / 100μlE20-74924-Cy5$485 / 100μlE20-74924-Cy5.5$485 / 100μlE20-74924-Cy7$485 / 100μlE20-74924-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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