World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
XRN2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight108582Da
Protein Name5'-3' exoribonuclease 2
Human Gene Id22803
Human Swiss Prot NoQ9H0D6
Mouse Gene Id24128
Mouse Swiss Prot NoQ9DBR1
SpecificityXRN2 Polyclonal Antibody detects endogenous levels of XRN2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameXRN2; 5'-3' exoribonuclease 2; DHM1-like protein; DHP protein
Observed Band(KD)108
Functioncatalytic activity:Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates.,function:Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.,similarity:Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.,similarity:Contains 1 CCHC-type zinc finger.,tissue specificity:Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2
Subcellular LocationNucleus, nucleolus .
ExpressionExpressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human XRN2. AA range:81-130
Gene NameXRN2
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Background5'-3' exoribonuclease 2(XRN2) Homo sapiens This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-74922-Conjugate. Price: $485 / Size: 100μl.
E20-74922-FITC$485 / 100μlE20-74922-Biotin$485 / 100μlE20-74922-HRP$485 / 100μlE20-74922-AP$485 / 100μlE20-74922-AF350$485 / 100μlE20-74922-AF405M$485 / 100μlE20-74922-AF488$485 / 100μlE20-74922-AF514$485 / 100μlE20-74922-AF532$485 / 100μlE20-74922-AF555$485 / 100μlE20-74922-AF568$485 / 100μlE20-74922-AF405S$485 / 100μlE20-74922-AF405L$485 / 100μlE20-74922-AF546$485 / 100μlE20-74922-AF594$485 / 100μlE20-74922-AF610$485 / 100μlE20-74922-AF635$485 / 100μlE20-74922-AF647$485 / 100μlE20-74922-AF680$485 / 100μlE20-74922-AF700$485 / 100μlE20-74922-AF750$485 / 100μlE20-74922-AF790$485 / 100μlE20-74922-APC$485 / 100μlE20-74922-PE$485 / 100μlE20-74922-Cy3$485 / 100μlE20-74922-Cy5$485 / 100μlE20-74922-Cy5.5$485 / 100μlE20-74922-Cy7$485 / 100μlE20-74922-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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