World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
XRCC1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight69526Da
Protein NameDNA repair protein XRCC1
Human Gene Id7515
Human Swiss Prot NoP18887
Mouse Gene Id22594
Mouse Swiss Prot NoQ60596
Rat Gene Id84495
Rat Swiss Prot NoQ9ESZ0
SpecificityXRCC1 Polyclonal Antibody detects endogenous levels of XRCC1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameXRCC1; DNA repair protein XRCC1; X-ray repair cross-complementing protein 1
Observed Band(KD)70
Functionfunction:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,
Subcellular LocationNucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. .
ExpressionExpressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human XRCC1. AA range:517-566
Gene NameXRCC1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
BackgroundX-ray repair cross complementing 1(XRCC1) Homo sapiens The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74917-Conjugate. Price: $485 / Size: 100μl.
E20-74917-FITC$485 / 100μlE20-74917-Biotin$485 / 100μlE20-74917-HRP$485 / 100μlE20-74917-AP$485 / 100μlE20-74917-AF350$485 / 100μlE20-74917-AF405M$485 / 100μlE20-74917-AF488$485 / 100μlE20-74917-AF514$485 / 100μlE20-74917-AF532$485 / 100μlE20-74917-AF555$485 / 100μlE20-74917-AF568$485 / 100μlE20-74917-AF405S$485 / 100μlE20-74917-AF405L$485 / 100μlE20-74917-AF546$485 / 100μlE20-74917-AF594$485 / 100μlE20-74917-AF610$485 / 100μlE20-74917-AF635$485 / 100μlE20-74917-AF647$485 / 100μlE20-74917-AF680$485 / 100μlE20-74917-AF700$485 / 100μlE20-74917-AF750$485 / 100μlE20-74917-AF790$485 / 100μlE20-74917-APC$485 / 100μlE20-74917-PE$485 / 100μlE20-74917-Cy3$485 / 100μlE20-74917-Cy5$485 / 100μlE20-74917-Cy5.5$485 / 100μlE20-74917-Cy7$485 / 100μlE20-74917-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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