World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
XPLN Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight59783Da
Protein NameRho guanine nucleotide exchange factor 3
Human Gene Id50650
Human Swiss Prot NoQ9NR81
Mouse Gene Id71704
Mouse Swiss Prot NoQ91X46
SpecificityXPLN Polyclonal Antibody detects endogenous levels of XPLN protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameARHGEF3; Rho guanine nucleotide exchange factor 3; Exchange factor found in platelets and leukemic and neuronal tissues; XPLN
Observed Band(KD)55
Functionfunction:Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,subunit:Interacts with RHOA and RHOB.,tissue specificity:Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.,
Subcellular LocationCytoplasm .
ExpressionWidely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human ARHGEF3. AA range:456-505
Gene NameARHGEF3
DilutionWestern Blot: 1/500 - 1/2000.IHC-p:1:50-300 ELISA: 1/20000. Not yet tested in other applications.
BackgroundRho guanine nucleotide exchange factor 3(ARHGEF3) Homo sapiens Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74916-Conjugate. Price: $485 / Size: 100μl.
E20-74916-FITC$485 / 100μlE20-74916-Biotin$485 / 100μlE20-74916-HRP$485 / 100μlE20-74916-AP$485 / 100μlE20-74916-AF350$485 / 100μlE20-74916-AF405M$485 / 100μlE20-74916-AF488$485 / 100μlE20-74916-AF514$485 / 100μlE20-74916-AF532$485 / 100μlE20-74916-AF555$485 / 100μlE20-74916-AF568$485 / 100μlE20-74916-AF405S$485 / 100μlE20-74916-AF405L$485 / 100μlE20-74916-AF546$485 / 100μlE20-74916-AF594$485 / 100μlE20-74916-AF610$485 / 100μlE20-74916-AF635$485 / 100μlE20-74916-AF647$485 / 100μlE20-74916-AF680$485 / 100μlE20-74916-AF700$485 / 100μlE20-74916-AF750$485 / 100μlE20-74916-AF790$485 / 100μlE20-74916-APC$485 / 100μlE20-74916-PE$485 / 100μlE20-74916-Cy3$485 / 100μlE20-74916-Cy5$485 / 100μlE20-74916-Cy5.5$485 / 100μlE20-74916-Cy7$485 / 100μlE20-74916-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits