XPA Polyclonal Antibody

Name: XPA Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-74914
Price: 225 USD
Availability: InStock

E20-74914Cite ID: EN0055047Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight31368Da

Protein NameDNA repair protein complementing XP-A cells

Human Gene Id7507

Human Swiss Prot NoP23025

Mouse Gene Id22590

Mouse Swiss Prot NoQ64267

SpecificityXPA Polyclonal Antibody detects endogenous levels of XPA protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameXPA; XPAC; DNA repair protein complementing XP-A cells; Xeroderma pigmentosum group A-complementing protein

Observed Band(KD)40

Functiondisease:Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.,function:Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the XPA family.,subun

Subcellular LocationNucleus .

ExpressionExpressed in various cell lines and in skin fibroblasts.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human XPA. AA range:211-260

Gene NameXPA

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

BackgroundXPA, DNA damage recognition and repair factor(XPA) Homo sapiens This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-74914-Conjugate. Price: $485 / Size: 100μl.

E20-74914-FITC$485 / 100μlE20-74914-Biotin$485 / 100μlE20-74914-HRP$485 / 100μlE20-74914-AP$485 / 100μlE20-74914-AF350$485 / 100μlE20-74914-AF405M$485 / 100μlE20-74914-AF488$485 / 100μlE20-74914-AF514$485 / 100μlE20-74914-AF532$485 / 100μlE20-74914-AF555$485 / 100μlE20-74914-AF568$485 / 100μlE20-74914-AF405S$485 / 100μlE20-74914-AF405L$485 / 100μlE20-74914-AF546$485 / 100μlE20-74914-AF594$485 / 100μlE20-74914-AF610$485 / 100μlE20-74914-AF635$485 / 100μlE20-74914-AF647$485 / 100μlE20-74914-AF680$485 / 100μlE20-74914-AF700$485 / 100μlE20-74914-AF750$485 / 100μlE20-74914-AF790$485 / 100μlE20-74914-APC$485 / 100μlE20-74914-PE$485 / 100μlE20-74914-Cy3$485 / 100μlE20-74914-Cy5$485 / 100μlE20-74914-Cy5.5$485 / 100μlE20-74914-Cy7$485 / 100μlE20-74914-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.