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WWOX Polyclonal Antibody
Datasheet
Catalog Number:
E20-74909Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human WWOX. AA range:1-50Source:
Polyclonal, RabbitGene Name:
WWOXDilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
- Western blot analysis of lysates from HepG2 cells, using WWOX Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
WWOX (WW domain containing oxidoreductase) encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. WWOX spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of WWOX is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.Protein Name:
WW domain-containing oxidoreductaseHuman Gene Id:
51741Human Swiss Prot No:
Q9NZC7Mouse Gene Id:
80707Mouse Swiss Prot No:
Q91WL8Specificity:
WWOX Polyclonal Antibody detects endogenous levels of WWOX protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
WWOX; FOR; WOX1; WW domain-containing oxidoreductase; Fragile site FRA16D oxidoreductaseMolecularWeight(Da):
46677Observed Band(KD):
47Function:
skeletal system development, ossification, osteoblast differentiation, induction of apoptosis, steroid metabolic process, negative regulation of signal transduction, negative regulation of cell communication, regulation of cell death,positive regulation of cell death, induction of programmed cell death, regulation of Wnt receptor signaling pathway,negative regulation of Wnt receptor signaling pathway, regulation of apoptosis, positive regulation of apoptosis,regulation of programmed cell death, positive regulation of programmed cell death, skeletal system morphogenesis,oxidation reduction, bone development,
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