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Cell Signal Transduction Research Antibodies
WBSCR11 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight106057Da
Protein NameGeneral transcription factor II-I repeat domain-containing protein 1
Human Gene Id9569
Human Swiss Prot NoQ9UHL9
Mouse Gene Id57080
Mouse Swiss Prot NoQ9JI57
SpecificityWBSCR11 Polyclonal Antibody detects endogenous levels of WBSCR11 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGTF2IRD1; CREAM1; GTF3; MUSTRD1; RBAP2; WBSCR11; WBSCR12; General transcription factor II-I repeat domain-containing protein 1; GTF2I repeat domain-containing protein 1; General transcription factor III; MusTRD1/BEN; Muscle TFII-I repeat do
Observed Band(KD)106
Functiondevelopmental stage:Highly expressed in developing and regenerating muscles, at the time of myofiber diversification.,disease:Haploinsufficiency of GTF2IRD1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,domain:The N-terminal half may have an activating activity.,function:May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity t
Subcellular LocationNucleus.
ExpressionHighly expressed in adult skeletal muscle, heart, fibroblast, bone and fetal tissues. Expressed at lower levels in all other tissues tested.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human GTF2IRD1. AA range:71-120
Gene NameGTF2IRD1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundGTF2I repeat domain containing 1(GTF2IRD1) Homo sapiens The protein encoded by this gene contains five GTF2I-like repeats and each repeat possesses a potential helix-loop-helix (HLH) motif. It may have the ability to interact with other HLH-proteins and function as a transcription factor or as a positive transcriptional regulator under the control of Retinoblastoma protein. This gene plays a role in craniofacial and cognitive development and mutations have been associated with Williams-Beuren syndrome, a multisystem developmental disorder caused by deletion of multiple genes at 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-74901-Conjugate. Price: $485 / Size: 100μl.
E20-74901-FITC$485 / 100μlE20-74901-Biotin$485 / 100μlE20-74901-HRP$485 / 100μlE20-74901-AP$485 / 100μlE20-74901-AF350$485 / 100μlE20-74901-AF405M$485 / 100μlE20-74901-AF488$485 / 100μlE20-74901-AF514$485 / 100μlE20-74901-AF532$485 / 100μlE20-74901-AF555$485 / 100μlE20-74901-AF568$485 / 100μlE20-74901-AF405S$485 / 100μlE20-74901-AF405L$485 / 100μlE20-74901-AF546$485 / 100μlE20-74901-AF594$485 / 100μlE20-74901-AF610$485 / 100μlE20-74901-AF635$485 / 100μlE20-74901-AF647$485 / 100μlE20-74901-AF680$485 / 100μlE20-74901-AF700$485 / 100μlE20-74901-AF750$485 / 100μlE20-74901-AF790$485 / 100μlE20-74901-APC$485 / 100μlE20-74901-PE$485 / 100μlE20-74901-Cy3$485 / 100μlE20-74901-Cy5$485 / 100μlE20-74901-Cy5.5$485 / 100μlE20-74901-Cy7$485 / 100μlE20-74901-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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