Product Information
Molecular Weight55293Da
Protein NameWiskott-Aldrich syndrome protein family member 3
Human Gene Id10810
Human Swiss Prot NoQ9UPY6
Mouse Gene Id245880
Mouse Swiss Prot NoQ8VHI6
SpecificityWAVE3 Polyclonal Antibody detects endogenous levels of WAVE3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameWASF3; KIAA0900; SCAR3; WAVE3; Wiskott-Aldrich syndrome protein family member 3; WASP family protein member 3; Protein WAVE-3; Verprolin homology domain-containing protein 3
Observed Band(KD)55
Functiondomain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subunit:Binds actin and the Arp2/3 complex.,tissue specificity:Expressed in ovary and brain.,
Subcellular Locationcytoplasm,cytoskeleton,lamellipodium,extracellular exosome,
ExpressionBrain,
BackgroundWAS protein family member 3(WASF3) Homo sapiens This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants [provided by RefSeq, May 2014],