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Cell Signal Transduction Research Antibodies
WAVE1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight61652Da
Protein NameWiskott-Aldrich syndrome protein family member 1
Human Gene Id8936
Human Swiss Prot NoQ92558
Mouse Gene Id83767
Mouse Swiss Prot NoQ8R5H6
Rat Gene Id294568
Rat Swiss Prot NoQ5BJU7
SpecificityWAVE1 Polyclonal Antibody detects endogenous levels of WAVE1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameWASF1; KIAA0269; SCAR1; WAVE1; Wiskott-Aldrich syndrome protein family member 1; WASP family protein member 1; Protein WAVE-1; Verprolin homology domain-containing protein 1
Observed Band(KD)70
Functiondomain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subcellular location:Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.,subunit:Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Binds actin and the Arp2/3 complex. Interacts with BAIAP2.,tissue specificity:Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small in
Subcellular LocationCytoplasm, cytoskeleton . Cell junction, synapse . Cell junction, focal adhesion . Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097). Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503). In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity). .
ExpressionHighly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human WAVE1. AA range:91-140
Gene NameWASF1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
BackgroundWAS protein family member 1(WASF1) Homo sapiens The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74897-Conjugate. Price: $485 / Size: 100μl.
E20-74897-FITC$485 / 100μlE20-74897-Biotin$485 / 100μlE20-74897-HRP$485 / 100μlE20-74897-AP$485 / 100μlE20-74897-AF350$485 / 100μlE20-74897-AF405M$485 / 100μlE20-74897-AF488$485 / 100μlE20-74897-AF514$485 / 100μlE20-74897-AF532$485 / 100μlE20-74897-AF555$485 / 100μlE20-74897-AF568$485 / 100μlE20-74897-AF405S$485 / 100μlE20-74897-AF405L$485 / 100μlE20-74897-AF546$485 / 100μlE20-74897-AF594$485 / 100μlE20-74897-AF610$485 / 100μlE20-74897-AF635$485 / 100μlE20-74897-AF647$485 / 100μlE20-74897-AF680$485 / 100μlE20-74897-AF700$485 / 100μlE20-74897-AF750$485 / 100μlE20-74897-AF790$485 / 100μlE20-74897-APC$485 / 100μlE20-74897-PE$485 / 100μlE20-74897-Cy3$485 / 100μlE20-74897-Cy5$485 / 100μlE20-74897-Cy5.5$485 / 100μlE20-74897-Cy7$485 / 100μlE20-74897-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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