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Cell Signal Transduction Research Antibodies
WASP Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight52913Da
Protein NameWiskott-Aldrich syndrome protein
Human Gene Id7454
Human Swiss Prot NoP42768
Mouse Gene Id22376
Mouse Swiss Prot NoP70315
SpecificityWASP Polyclonal Antibody detects endogenous levels of WASP protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameWAS; IMD2; Wiskott-Aldrich syndrome protein; WASp
Observed Band(KD)60
Functiondisease:Defects in WAS are a cause of X-linked severe congenital neutropenia (XLN) [MIM:300299]. XLN is an X-linked immunodeficiency syndrome characterized by recurrent major bacterial infections, severe congenital neutropenia, and monocytopenia.,disease:Defects in WAS are the cause of thrombocytopenia type 1 (THC1) [MIM:313900]. Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.,disease:Defects in WAS are the cause of Wiskott-Aldrich syndrome (WAS) [MIM:301000]; also known as eczema-thrombocytopenia-immunodeficiency syndrome. WAS is an X-linked recessive immunodeficiency characterized by eczema, thrombocytopenia, recurrent infections, and bloody diarrhea. Death usually occurs before age 10.,domain:The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-ter
Subcellular LocationCytoplasm, cytoskeleton . Nucleus .
ExpressionExpressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human WASP. AA range:256-305
Gene NameWAS
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
BackgroundWiskott-Aldrich syndrome(WAS) Homo sapiens The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A t
Conjugated Antibody
This product is also available conjugated. Format: E20-74896-Conjugate. Price: $485 / Size: 100μl.
E20-74896-FITC$485 / 100μlE20-74896-Biotin$485 / 100μlE20-74896-HRP$485 / 100μlE20-74896-AP$485 / 100μlE20-74896-AF350$485 / 100μlE20-74896-AF405M$485 / 100μlE20-74896-AF488$485 / 100μlE20-74896-AF514$485 / 100μlE20-74896-AF532$485 / 100μlE20-74896-AF555$485 / 100μlE20-74896-AF568$485 / 100μlE20-74896-AF405S$485 / 100μlE20-74896-AF405L$485 / 100μlE20-74896-AF546$485 / 100μlE20-74896-AF594$485 / 100μlE20-74896-AF610$485 / 100μlE20-74896-AF635$485 / 100μlE20-74896-AF647$485 / 100μlE20-74896-AF680$485 / 100μlE20-74896-AF700$485 / 100μlE20-74896-AF750$485 / 100μlE20-74896-AF790$485 / 100μlE20-74896-APC$485 / 100μlE20-74896-PE$485 / 100μlE20-74896-Cy3$485 / 100μlE20-74896-Cy5$485 / 100μlE20-74896-Cy5.5$485 / 100μlE20-74896-Cy7$485 / 100μlE20-74896-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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