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Cell Signal Transduction Research Antibodies
VEGI Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight28087Da
Protein NameTumor necrosis factor ligand superfamily member 15
Human Gene Id9966
Human Swiss Prot NoO95150
Mouse Gene Id326623
Mouse Swiss Prot NoQ5UBV8
Rat Gene Id252878
Rat Swiss Prot NoQ8K3Y7
SpecificityVEGI Polyclonal Antibody detects endogenous levels of VEGI protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTNFSF15; TL1; VEGI; Tumor necrosis factor ligand superfamily member 15; TNF ligand-related molecule 1; Vascular endothelial cell growth inhibitor
Observed Band(KD)28
Functionfunction:Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.,induction:Up-regulated by IL-1-alpha and TNF-alpha.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,tissue specificity:Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.,
Subcellular LocationMembrane ; Single-pass type II membrane protein .; [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted.
ExpressionSpecifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from Tumor necrosis factor ligand superfamily member 15 at AA range: 51-100
Gene NameTNFSF15
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundtumor necrosis factor superfamily member 15(TNFSF15) Homo sapiens The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-74873-Conjugate. Price: $485 / Size: 100μl.
E20-74873-FITC$485 / 100μlE20-74873-Biotin$485 / 100μlE20-74873-HRP$485 / 100μlE20-74873-AP$485 / 100μlE20-74873-AF350$485 / 100μlE20-74873-AF405M$485 / 100μlE20-74873-AF488$485 / 100μlE20-74873-AF514$485 / 100μlE20-74873-AF532$485 / 100μlE20-74873-AF555$485 / 100μlE20-74873-AF568$485 / 100μlE20-74873-AF405S$485 / 100μlE20-74873-AF405L$485 / 100μlE20-74873-AF546$485 / 100μlE20-74873-AF594$485 / 100μlE20-74873-AF610$485 / 100μlE20-74873-AF635$485 / 100μlE20-74873-AF647$485 / 100μlE20-74873-AF680$485 / 100μlE20-74873-AF700$485 / 100μlE20-74873-AF750$485 / 100μlE20-74873-AF790$485 / 100μlE20-74873-APC$485 / 100μlE20-74873-PE$485 / 100μlE20-74873-Cy3$485 / 100μlE20-74873-Cy5$485 / 100μlE20-74873-Cy5.5$485 / 100μlE20-74873-Cy7$485 / 100μlE20-74873-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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