Product Information
Molecular Weight21602Da
Protein NameVascular endothelial growth factor B
Human Gene Id7423
Human Swiss Prot NoP49765
Mouse Gene Id22340
Mouse Swiss Prot NoP49766
Rat Gene Id89811
Rat Swiss Prot NoO35485
SpecificityVEGF-B Polyclonal Antibody detects endogenous levels of VEGF-B protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameVEGFB; VRF; Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF
Observed Band(KD)21
Functionalternative products:Additional isoforms seem to exist,function:Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.,PTM:VEGF-B186 is O-glycosylated.,similarity:Belongs to the PDGF/VEGF growth factor family.,subcellular location:Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.,subunit:Homodimer; disulfide-linked. Can also form heterodimer with VEGF.,tissue specificity:Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.,
Subcellular LocationSecreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
ExpressionExpressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Backgroundvascular endothelial growth factor B(VEGFB) Homo sapiens This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011],