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Cell Signal Transduction Research Antibodies
VDR Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight48289Da
Protein NameVitamin D3 receptor
Human Gene Id7421
Human Swiss Prot NoP11473
Mouse Swiss Prot NoP48281
SpecificityVDR Polyclonal Antibody detects endogenous levels of VDR protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameVDR; NR1I1; Vitamin D3 receptor; VDR; 1; 25-dihydroxyvitamin D3 receptor; Nuclear receptor subfamily 1 group I member 1
Observed Band(KD)38
Functioncaution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in VDR are the cause of type IIA rickets [MIM:277440]; also known as hypocalcemic vitamin D-resistant rickets (HVDRR). HVDRR is most frequently an autosomal recessive disorder characterized by severe rickets, hypocalcemia and secondary hyperparathyroidism.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essentia
Subcellular LocationNucleus . Cytoplasm . Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Localization to the nucleus is enhanced by vitamin D3. .
ExpressionLens epithelium,Peripheral blood,Placenta,Rectum,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Vitamin D Receptor. AA range:181-230
Gene NameVDR
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundvitamin D (1,25- dihydroxyvitamin D3) receptor(VDR) Homo sapiens This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-74868-Conjugate. Price: $485 / Size: 100μl.
E20-74868-FITC$485 / 100μlE20-74868-Biotin$485 / 100μlE20-74868-HRP$485 / 100μlE20-74868-AP$485 / 100μlE20-74868-AF350$485 / 100μlE20-74868-AF405M$485 / 100μlE20-74868-AF488$485 / 100μlE20-74868-AF514$485 / 100μlE20-74868-AF532$485 / 100μlE20-74868-AF555$485 / 100μlE20-74868-AF568$485 / 100μlE20-74868-AF405S$485 / 100μlE20-74868-AF405L$485 / 100μlE20-74868-AF546$485 / 100μlE20-74868-AF594$485 / 100μlE20-74868-AF610$485 / 100μlE20-74868-AF635$485 / 100μlE20-74868-AF647$485 / 100μlE20-74868-AF680$485 / 100μlE20-74868-AF700$485 / 100μlE20-74868-AF750$485 / 100μlE20-74868-AF790$485 / 100μlE20-74868-APC$485 / 100μlE20-74868-PE$485 / 100μlE20-74868-Cy3$485 / 100μlE20-74868-Cy5$485 / 100μlE20-74868-Cy5.5$485 / 100μlE20-74868-Cy7$485 / 100μlE20-74868-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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