Product Information
Molecular Weight101257Da
Protein NameGuanine nucleotide exchange factor VAV2
Human Gene Id7410
Human Swiss Prot NoP52735
Mouse Gene Id22325
Mouse Swiss Prot NoQ60992
SpecificityVav2 Polyclonal Antibody detects endogenous levels of Vav2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameVAV2; Guanine nucleotide exchange factor VAV2; VAV-2
Observed Band(KD)101
Functionfunction:Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,tissue specificity:Widely expressed.,
Subcellular Locationcytosol,plasma membrane,
ExpressionWidely expressed.
Backgroundvav guanine nucleotide exchange factor 2(VAV2) Homo sapiens VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],