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Cell Signal Transduction Research Antibodies
Vav1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight98314Da
Protein NameProto-oncogene vav
Human Gene Id7409
Human Swiss Prot NoP15498
Mouse Gene Id22324
Mouse Swiss Prot NoP27870
Rat Swiss Prot NoP54100
SpecificityVAV1 Polyclonal Antibody detects endogenous levels of VAV1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameVAV1; VAV; Proto-oncogene vav
Observed Band(KD)98
Functiondomain:The DH domain is involved in interaction with CCPG1.,function:Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.,miscellaneous:'Vav' stands for the sixth letter of the Hebrew alphabet.,PTM:Phosphorylated on tyrosine residues.,similarity:Contains 1 CH (calponin-homology) domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylati
Subcellular Locationintracellular,cytosol,plasma membrane,cell-cell junction,
ExpressionWidely expressed in hematopoietic cells but not in other cell types.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human VAV1. AA range:131-180
Gene NameVAV1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Backgroundvav guanine nucleotide exchange factor 1(VAV1) Homo sapiens This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012],
Conjugated Antibody
This product is also available conjugated. Format: E20-74863-Conjugate. Price: $485 / Size: 100μl.
E20-74863-FITC$485 / 100μlE20-74863-Biotin$485 / 100μlE20-74863-HRP$485 / 100μlE20-74863-AP$485 / 100μlE20-74863-AF350$485 / 100μlE20-74863-AF405M$485 / 100μlE20-74863-AF488$485 / 100μlE20-74863-AF514$485 / 100μlE20-74863-AF532$485 / 100μlE20-74863-AF555$485 / 100μlE20-74863-AF568$485 / 100μlE20-74863-AF405S$485 / 100μlE20-74863-AF405L$485 / 100μlE20-74863-AF546$485 / 100μlE20-74863-AF594$485 / 100μlE20-74863-AF610$485 / 100μlE20-74863-AF635$485 / 100μlE20-74863-AF647$485 / 100μlE20-74863-AF680$485 / 100μlE20-74863-AF700$485 / 100μlE20-74863-AF750$485 / 100μlE20-74863-AF790$485 / 100μlE20-74863-APC$485 / 100μlE20-74863-PE$485 / 100μlE20-74863-Cy3$485 / 100μlE20-74863-Cy5$485 / 100μlE20-74863-Cy5.5$485 / 100μlE20-74863-Cy7$485 / 100μlE20-74863-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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