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Cell Signal Transduction Research Antibodies
Vasohibin Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight40957Da
Protein NameVasohibin-1
Human Gene Id22846
Human Swiss Prot NoQ7L8A9
Mouse Gene Id238328
Mouse Swiss Prot NoQ8C1W1
SpecificityVasohibin Polyclonal Antibody detects endogenous levels of Vasohibin protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameVASH1; KIAA1036; VASH; Vasohibin-1
Observed Band(KD)40
Functioncaution:Although probably secreted, it lacks a canonical signal sequence.,function:Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.,induction:By VEGF.,PTM:2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may corre
Subcellular LocationCytoplasm . Secreted . Mainly localizes in the cytoplasm (PubMed:27879017). Some fraction is secreted via a non-canonical secretion system; interaction with SVBP promotes secretion (PubMed:27879017). .
ExpressionPreferentially expressed in endothelial cells (PubMed:15467828, PubMed:16707096). Highly expressed in fetal organs (PubMed:15467828). Expressed in brain and placenta, and at lower level in heart and kidney (PubMed:15467828). Highly detected in microvessels endothelial cells of atherosclerotic lesions (PubMed:16707096).
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human VASH1. AA range:261-310
Gene NameVASH1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Backgroundcaution:Although probably secreted, it lacks a canonical signal sequence.,function:Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity.,induction:By VEGF.,PTM:2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage. The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu. Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form.,similarity:Belongs to the vasohibin family.,tissue specificity:Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.,
Conjugated Antibody
This product is also available conjugated. Format: E20-74853-Conjugate. Price: $485 / Size: 100μl.
E20-74853-FITC$485 / 100μlE20-74853-Biotin$485 / 100μlE20-74853-HRP$485 / 100μlE20-74853-AP$485 / 100μlE20-74853-AF350$485 / 100μlE20-74853-AF405M$485 / 100μlE20-74853-AF488$485 / 100μlE20-74853-AF514$485 / 100μlE20-74853-AF532$485 / 100μlE20-74853-AF555$485 / 100μlE20-74853-AF568$485 / 100μlE20-74853-AF405S$485 / 100μlE20-74853-AF405L$485 / 100μlE20-74853-AF546$485 / 100μlE20-74853-AF594$485 / 100μlE20-74853-AF610$485 / 100μlE20-74853-AF635$485 / 100μlE20-74853-AF647$485 / 100μlE20-74853-AF680$485 / 100μlE20-74853-AF700$485 / 100μlE20-74853-AF750$485 / 100μlE20-74853-AF790$485 / 100μlE20-74853-APC$485 / 100μlE20-74853-PE$485 / 100μlE20-74853-Cy3$485 / 100μlE20-74853-Cy5$485 / 100μlE20-74853-Cy5.5$485 / 100μlE20-74853-Cy7$485 / 100μlE20-74853-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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