USP16 Polyclonal Antibody

Name: USP16 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-74831
Price: 225 USD
Availability: InStock

E20-74831Cite ID: EN0054964Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight93570 Da

Protein NameUbiquitin carboxyl-terminal hydrolase 16

Human Gene Id10600

Human Swiss Prot NoQ9Y5T5

Mouse Gene Id74112

Mouse Swiss Prot NoQ99LG0

Rat Gene Id288306

Rat Swiss Prot NoQ2KJ09

SpecificityUSP16 Polyclonal Antibody detects endogenous levels of USP16 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameUSP16; MSTP039; Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-processing protease UBP-M; Ubiquitin-specific-processing protease 16

Observed Band(KD)93

Functioncatalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,disease:A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.,domain:The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin.,function:Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.,PTM:Ph

Subcellular Locationnucleus,cytoplasm,

ExpressionAmygdala,Aorta,Brain,Epithelium,Liver,Teratocarcinoma,Testis,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenSynthesized peptide derived from the Internal region of human USP16.

Gene NameUSP16

DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Backgroundubiquitin specific peptidase 16(USP16) Homo sapiens This gene encodes a deubiquitinating enzyme that is phosphorylated at the onset of mitosis and then dephosphorylated at the metaphase/anaphase transition. It can deubiquitinate H2A, one of two major ubiquitinated proteins of chromatin, in vitro and a mutant form of the protein was shown to block cell division. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-74831-Conjugate. Price: $485 / Size: 100μl.

E20-74831-FITC$485 / 100μlE20-74831-Biotin$485 / 100μlE20-74831-HRP$485 / 100μlE20-74831-AP$485 / 100μlE20-74831-AF350$485 / 100μlE20-74831-AF405M$485 / 100μlE20-74831-AF488$485 / 100μlE20-74831-AF514$485 / 100μlE20-74831-AF532$485 / 100μlE20-74831-AF555$485 / 100μlE20-74831-AF568$485 / 100μlE20-74831-AF405S$485 / 100μlE20-74831-AF405L$485 / 100μlE20-74831-AF546$485 / 100μlE20-74831-AF594$485 / 100μlE20-74831-AF610$485 / 100μlE20-74831-AF635$485 / 100μlE20-74831-AF647$485 / 100μlE20-74831-AF680$485 / 100μlE20-74831-AF700$485 / 100μlE20-74831-AF750$485 / 100μlE20-74831-AF790$485 / 100μlE20-74831-APC$485 / 100μlE20-74831-PE$485 / 100μlE20-74831-Cy3$485 / 100μlE20-74831-Cy5$485 / 100μlE20-74831-Cy5.5$485 / 100μlE20-74831-Cy7$485 / 100μlE20-74831-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.