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uPA Polyclonal Antibody
Datasheet
Catalog Number:
E20-74823Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human uPA. AA range:190-239Source:
Polyclonal, RabbitGene Name:
PLAUDilution:
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Immunohistochemistry analysis of uPA antibody in paraffin-embedded human brain tissue.
Background:
plasminogen activator, urokinase(PLAU) Homo sapiens This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],Protein Name:
Urokinase-type plasminogen activatorHuman Gene Id:
5328Human Swiss Prot No:
P00749Mouse Swiss Prot No:
P06869Specificity:
uPA Polyclonal Antibody detects endogenous levels of uPA protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
PLAU; Urokinase-type plasminogen activator; U-plasminogen activator; uPAMolecularWeight(Da):
48525Function:
catalytic activity:Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.,function:Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.,online information:Urokinase entry,pharmaceutical:Available under the name Abbokinase (Abbott). Used in Pulmonary Embolism (PE) to initiates fibrinolysis. Clinically used for therapy of thrombolytic disorders.,PTM:Phosphorylation of Ser-158 and Ser-323 abolishes proadhesive ability but does not interfere with receptor binding.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 peptidase S1 domain.,subunit:Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internaSubcellular Location:
extracellular region,extracellular space,plasma membrane,focal adhesion,cell surface,extracellular exosome,Expression:
Brain,Lung,
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Catalog Number
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