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Cell Signal Transduction Research Antibodies
UDG Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight34645Da
Protein NameUracil-DNA glycosylase
Human Gene Id7374
Human Swiss Prot NoP13051
Mouse Gene Id22256
Mouse Swiss Prot NoP97931
SpecificityUDG Polyclonal Antibody detects endogenous levels of UDG protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameUNG; DGU; UNG1; UNG15; Uracil-DNA glycosylase; UDG
Observed Band(KD)35
Functiondisease:Defects in UNG are a cause of immunodeficiency with hyper-IgM type 5 syndrome (HIGM5) [MIM:608106]. Hyper-IgM syndrome is a condition characterized by normal or increased serum IgM concentrations associated with low or absent serum IgG, IgA, and IgE concentrations. HIGM5 is associated with profound impairment in immunoglobulin (Ig) class-switch recombination (CSR) at a DNA precleavage step.,function:Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.,online information:UNG mutation db,PTM:Isoform 1 is processed by cleavage of a transit peptide.,similarity:Belongs to the uracil-DNA glycosylase family.,subunit:Monomer. Interacts with HIV-1 Vpr.,tissue specificity:Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the hi
Subcellular Location[Isoform 1]: Mitochondrion.; [Isoform 2]: Nucleus.
ExpressionIsoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human UNG. AA range:191-240
Gene NameUNG
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Backgrounduracil DNA glycosylase(UNG) Homo sapiens This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-74815-Conjugate. Price: $485 / Size: 100μl.
E20-74815-FITC$485 / 100μlE20-74815-Biotin$485 / 100μlE20-74815-HRP$485 / 100μlE20-74815-AP$485 / 100μlE20-74815-AF350$485 / 100μlE20-74815-AF405M$485 / 100μlE20-74815-AF488$485 / 100μlE20-74815-AF514$485 / 100μlE20-74815-AF532$485 / 100μlE20-74815-AF555$485 / 100μlE20-74815-AF568$485 / 100μlE20-74815-AF405S$485 / 100μlE20-74815-AF405L$485 / 100μlE20-74815-AF546$485 / 100μlE20-74815-AF594$485 / 100μlE20-74815-AF610$485 / 100μlE20-74815-AF635$485 / 100μlE20-74815-AF647$485 / 100μlE20-74815-AF680$485 / 100μlE20-74815-AF700$485 / 100μlE20-74815-AF750$485 / 100μlE20-74815-AF790$485 / 100μlE20-74815-APC$485 / 100μlE20-74815-PE$485 / 100μlE20-74815-Cy3$485 / 100μlE20-74815-Cy5$485 / 100μlE20-74815-Cy5.5$485 / 100μlE20-74815-Cy7$485 / 100μlE20-74815-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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