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Cell Signal Transduction Research Antibodies
UBR5 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight309352Da
Protein NameE3 ubiquitin-protein ligase UBR5
Human Gene Id51366
Human Swiss Prot NoO95071
Mouse Gene Id70790
Mouse Swiss Prot NoQ80TP3
SpecificityUBR5 Polyclonal Antibody detects endogenous levels of UBR5 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameUBR5; EDD; EDD1; HYD; KIAA0896; E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase; HECT domain-containing 1; Hyperplastic discs protein homolog; hHYD; Progestin-induced protein
Observed Band(KD)309
Functionfunction:E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). May be involved in maturation and/or transcriptional regulation of mRNA. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development.,miscellaneous:A cysteine residue is required for ubiquitin-thioester formation.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 1 PABC domain.,similar
Subcellular LocationNucleus.
ExpressionWidely expressed. Most abundant in testis and expressed at high levels in brain, pituitary and kidney.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human EDD. AA range:1-50
Gene NameUBR5
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Backgroundubiquitin protein ligase E3 component n-recognin 5(UBR5) Homo sapiens This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74809-Conjugate. Price: $485 / Size: 100μl.
E20-74809-FITC$485 / 100μlE20-74809-Biotin$485 / 100μlE20-74809-HRP$485 / 100μlE20-74809-AP$485 / 100μlE20-74809-AF350$485 / 100μlE20-74809-AF405M$485 / 100μlE20-74809-AF488$485 / 100μlE20-74809-AF514$485 / 100μlE20-74809-AF532$485 / 100μlE20-74809-AF555$485 / 100μlE20-74809-AF568$485 / 100μlE20-74809-AF405S$485 / 100μlE20-74809-AF405L$485 / 100μlE20-74809-AF546$485 / 100μlE20-74809-AF594$485 / 100μlE20-74809-AF610$485 / 100μlE20-74809-AF635$485 / 100μlE20-74809-AF647$485 / 100μlE20-74809-AF680$485 / 100μlE20-74809-AF700$485 / 100μlE20-74809-AF750$485 / 100μlE20-74809-AF790$485 / 100μlE20-74809-APC$485 / 100μlE20-74809-PE$485 / 100μlE20-74809-Cy3$485 / 100μlE20-74809-Cy5$485 / 100μlE20-74809-Cy5.5$485 / 100μlE20-74809-Cy7$485 / 100μlE20-74809-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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