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Cell Signal Transduction Research Antibodies
Ubr1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight119545Da
Protein NameMitotic checkpoint serine/threonine-protein kinase BUB1 beta
Human Gene Id701
Human Swiss Prot NoO60566
Mouse Gene Id12236
Mouse Swiss Prot NoQ9Z1S0
SpecificityBubR1 Polyclonal Antibody detects endogenous levels of BubR1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBUB1B; BUBR1; MAD3L; SSK1; Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MAD3/BUB1-related protein kinase; hBUBR1; Mitotic checkpoint kinase MAD3L; Protein SSK1
Observed Band(KD)130
Functioncatalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in BUB1B are associated with tumor formation.,disease:Defects in BUB1B are the cause of mosaic variegated aneuploidy syndrome (MVA) [MIM:257300]. MVA is a severe autosomal recessive developmental disorder characterized by mosaic aneuploidies, predominantly trisomies and monosomies, involving multiple different chromosomes and tissues. The proportion of aneuploid cells varies but is usually more than 25% and is substantially greater than in normal individuals. Affected individuals typically present with severe intrauterine growth retardation and microcephaly. Eye anomalies, mild dysmorphism, variable developmental delay, and a broad spectrum of additional congenital abnormalities and medical conditions may also occur. The risk of malignancy is high, with rhabdomyosarcoma, Wilms tumor and leukemia reported in seve
Subcellular LocationCytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, PLK1 and KNL1.
ExpressionHighly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human BUB1B. AA range:341-390
Gene NameBUB1B
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
BackgroundBUB1 mitotic checkpoint serine/threonine kinase B(BUB1B) Homo sapiens This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74808-Conjugate. Price: $485 / Size: 100μl.
E20-74808-FITC$485 / 100μlE20-74808-Biotin$485 / 100μlE20-74808-HRP$485 / 100μlE20-74808-AP$485 / 100μlE20-74808-AF350$485 / 100μlE20-74808-AF405M$485 / 100μlE20-74808-AF488$485 / 100μlE20-74808-AF514$485 / 100μlE20-74808-AF532$485 / 100μlE20-74808-AF555$485 / 100μlE20-74808-AF568$485 / 100μlE20-74808-AF405S$485 / 100μlE20-74808-AF405L$485 / 100μlE20-74808-AF546$485 / 100μlE20-74808-AF594$485 / 100μlE20-74808-AF610$485 / 100μlE20-74808-AF635$485 / 100μlE20-74808-AF647$485 / 100μlE20-74808-AF680$485 / 100μlE20-74808-AF700$485 / 100μlE20-74808-AF750$485 / 100μlE20-74808-AF790$485 / 100μlE20-74808-APC$485 / 100μlE20-74808-PE$485 / 100μlE20-74808-Cy3$485 / 100μlE20-74808-Cy5$485 / 100μlE20-74808-Cy5.5$485 / 100μlE20-74808-Cy7$485 / 100μlE20-74808-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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