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Trk B Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-74744

  • Amount:

    100ul

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Trk B. AA range:671-720

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of various cells using Trk B Polyclonal Antibody diluted at 1:500. Secondary antibody was diluted at 1:20000

  • Gene Name:

    NTRK2

  • Dilution:

    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

  • Background:

    neurotrophic receptor tyrosine kinase 2(NTRK2) Homo sapiens This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

  • Protein Name:

    BDNF/NT-3 growth factors receptor

  • Human Gene Id:

    4915

  • Human Swiss Prot No:

    Q16620

  • Mouse Gene Id:

    18212

  • Mouse Swiss Prot No:

    P15209

  • Rat Gene Id:

    25054

  • Rat Swiss Prot No:

    Q63604

  • Specificity:

    Trk B Polyclonal Antibody detects endogenous levels of Trk B protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    NTRK2; TRKB; BDNF/NT-3 growth factors receptor; GP145-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B

  • MolecularWeight(Da):

    91999

  • Observed Band(KD):

    145

  • Function:

    alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.,PTM:Ligand-mediated auto-phosphorylation.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 2 LRR (leucine-rich) repeats.,subunit:Exists in a dynamic equ

  • Subcellular Location:

    endosome,cytosol,integral component of plasma membrane,endosome membrane,postsynaptic density,integral component of membrane,terminal bouton,receptor complex,postsynaptic membrane,

  • Expression:

    Brain,Corpus callosum,Hippocampus,Plasma,

  • Western Blot analysis of HepG2 cells using Trk B Polyclonal Antibody diluted at 1:500. Secondary antibody was diluted at 1:20000

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Catalog Number

  • Amount:100ul
  • Price:225$

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