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TRAC-1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-74715Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human RNF125. AA range:131-180Source:
Polyclonal, RabbitGene Name:
RNF125Dilution:
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
- Western blot analysis of lysates from K562 and HT-29 cells, using RNF125 Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
ring finger protein 125(RNF125) Homo sapiens This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012],Protein Name:
E3 ubiquitin-protein ligase RNF125Human Gene Id:
54941Human Swiss Prot No:
Q96EQ8Mouse Gene Id:
67664Mouse Swiss Prot No:
Q9D9R0Specificity:
TRAC-1 Polyclonal Antibody detects endogenous levels of TRAC-1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
RNF125; E3 ubiquitin-protein ligase RNF125; RING finger protein 125; T-cell RING activation protein 1; TRAC-1MolecularWeight(Da):
26454Observed Band(KD):
26Function:
function:E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-type zinc finger.,tissue specificity:Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4+ and CD8+ T-cells, suggesting that it is preferentially confined to T-cells.,Subcellular Location:
Golgi membrane,intracellular,intracellular membrane-bounded organelle,Expression:
B-cell,Colon,Skin,
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Catalog Number
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