Product Information
Molecular Weight38155Da
Protein NameProtein Tob1
Human Gene Id10140
Human Swiss Prot NoP50616
Mouse Swiss Prot NoQ61471
Rat Swiss Prot NoQ8R5K6
SpecificityTOB1 Polyclonal Antibody detects endogenous levels of TOB1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTOB1; TOB; TROB1; Protein Tob1; Transducer of erbB-2 1
Observed Band(KD)40
Functionfunction:Anti-proliferative protein that interacts with the erbB-2 receptor tyrosine kinase. May physically and/or functionally interact with protein-tyrosine kinase receptors.,PTM:Phosphorylated on Ser and Thr residues.,similarity:Belongs to the BTG family.,subunit:Interacts with CNOT7.,tissue specificity:Ubiquitous.,
Subcellular LocationCytoplasm . Nucleus . Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. .
ExpressionUbiquitous.
BackgroundThis gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011],