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Cell Signal Transduction Research Antibodies
TIRAP Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight23883Da
Protein NameToll/interleukin-1 receptor domain-containing adapter protein
Human Gene Id114609
Human Swiss Prot NoP58753
Mouse Gene Id117149
Mouse Swiss Prot NoQ99JY1
SpecificityTIRAP Polyclonal Antibody detects endogenous levels of TIRAP protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTIRAP; MAL; Toll/interleukin-1 receptor domain-containing adapter protein; TIR domain-containing adapter protein; Adaptor protein Wyatt; MyD88 adapter-like protein
Functionfunction:Adapter involved in the TLR4 signaling pathway in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, resulting in cytokine secretion and the inflammatory response.,polymorphism:Genetic variation in TIRAP can influence susceptibility or resistance to invasive pneumococcal disease, bacteremia, malaria and tuberculosi.,similarity:Contains 1 TIR domain.,subunit:Homodimer. Also forms heterodimers with MyD88. Binds to TLR4 and IRAK2 via their respective TIR domains. Binds to PKR and TBK1. Does not interact with IRAK1, nor TLR9.,tissue specificity:Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain.,
Subcellular Locationnucleoplasm,cytoplasm,cytosol,plasma membrane,endocytic vesicle,ruffle membrane,intercellular bridge,
ExpressionBlood,Brain,Dendritic cell,Trachea,,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human TIRAP. AA range:52-101
Gene NameTIRAP
DilutionWB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
BackgroundTIR domain containing adaptor protein(TIRAP) Homo sapiens The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74667-Conjugate. Price: $485 / Size: 100μl.
E20-74667-FITC$485 / 100μlE20-74667-Biotin$485 / 100μlE20-74667-HRP$485 / 100μlE20-74667-AP$485 / 100μlE20-74667-AF350$485 / 100μlE20-74667-AF405M$485 / 100μlE20-74667-AF488$485 / 100μlE20-74667-AF514$485 / 100μlE20-74667-AF532$485 / 100μlE20-74667-AF555$485 / 100μlE20-74667-AF568$485 / 100μlE20-74667-AF405S$485 / 100μlE20-74667-AF405L$485 / 100μlE20-74667-AF546$485 / 100μlE20-74667-AF594$485 / 100μlE20-74667-AF610$485 / 100μlE20-74667-AF635$485 / 100μlE20-74667-AF647$485 / 100μlE20-74667-AF680$485 / 100μlE20-74667-AF700$485 / 100μlE20-74667-AF750$485 / 100μlE20-74667-AF790$485 / 100μlE20-74667-APC$485 / 100μlE20-74667-PE$485 / 100μlE20-74667-Cy3$485 / 100μlE20-74667-Cy5$485 / 100μlE20-74667-Cy5.5$485 / 100μlE20-74667-Cy7$485 / 100μlE20-74667-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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