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Cell Signal Transduction Research Antibodies
TFIIE-β Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight37698DaObserved Band: 38KD
Protein NameTATA-box-binding protein
Human Gene Id6908
Human Swiss Prot NoP20226
Mouse Gene Id21374
Mouse Swiss Prot NoP29037
SpecificityTFIID Polyclonal Antibody detects endogenous levels of TFIID protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTBP; GTF2D1; TF2D; TFIID; TATA-box-binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box factor; Transcription initiation factor TFIID TBP subunit
Functiondisease:Defects in TBP are the cause of spinocerebellar ataxia type 17 (SCA17) [MIM:607136]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA17 is an autosomal dominant cerebellar ataxia (ADCA) characterized by widespread cerebral and cerebellar atrophy, dementia and extrapyramidal signs. The molecular defect in SCA17 is the expansion of a CAG repeat in the coding region of TBP. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.,function:General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the ini
Subcellular Locationnuclear chromatin,female pronucleus,male pronucleus,nucleus,nucleoplasm,transcription factor TFIID complex,transcription factor TFIIA complex,nuclear euchromatin,cytoplasm,
ExpressionFibroblast,Lung,PCR rescued clones,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human TBP. AA range:151-200
Gene NameTBP
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
BackgroundTATA-box binding protein(TBP) Homo sapiens Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA bin
Conjugated Antibody
This product is also available conjugated. Format: E20-74615-Conjugate. Price: $485 / Size: 100μl.
E20-74615-FITC$485 / 100μlE20-74615-Biotin$485 / 100μlE20-74615-HRP$485 / 100μlE20-74615-AP$485 / 100μlE20-74615-AF350$485 / 100μlE20-74615-AF405M$485 / 100μlE20-74615-AF488$485 / 100μlE20-74615-AF514$485 / 100μlE20-74615-AF532$485 / 100μlE20-74615-AF555$485 / 100μlE20-74615-AF568$485 / 100μlE20-74615-AF405S$485 / 100μlE20-74615-AF405L$485 / 100μlE20-74615-AF546$485 / 100μlE20-74615-AF594$485 / 100μlE20-74615-AF610$485 / 100μlE20-74615-AF635$485 / 100μlE20-74615-AF647$485 / 100μlE20-74615-AF680$485 / 100μlE20-74615-AF700$485 / 100μlE20-74615-AF750$485 / 100μlE20-74615-AF790$485 / 100μlE20-74615-APC$485 / 100μlE20-74615-PE$485 / 100μlE20-74615-Cy3$485 / 100μlE20-74615-Cy5$485 / 100μlE20-74615-Cy5.5$485 / 100μlE20-74615-Cy7$485 / 100μlE20-74615-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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