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Cell Signal Transduction Research Antibodies
TF Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight33068DaObserved Band:48KD
Protein NameTissue factor
Human Gene Id2152
Human Swiss Prot NoP13726
Mouse Swiss Prot NoP20352
SpecificityTF Polyclonal Antibody detects endogenous levels of TF protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameF3; Tissue factor; TF; Coagulation factor III; Thromboplastin; CD antigen CD142
Functionfunction:Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.,induction:TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.,online information:The Singapore human mutation and polymorphism database,online information:Tissue factor entry,similarity:Belongs to the tissue factor family.,
Subcellular Locationextracellular space,plasma membrane,cell surface,integral component of membrane,extracellular matrix,intrinsic component of external side of plasma membrane,extracellular exosome,serine-type peptidase complex,
ExpressionLung,Prostate,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Coagulation Factor III. AA range:246-295
Gene NameF3
DilutionWestern Blot:1/500 - 1/2000. ELISA:1/5000. Not yet tested in other applications.
Backgroundcoagulation factor III, tissue factor(F3) Homo sapiens This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor:extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-74610-Conjugate. Price: $485 / Size: 100μl.
E20-74610-FITC$485 / 100μlE20-74610-Biotin$485 / 100μlE20-74610-HRP$485 / 100μlE20-74610-AP$485 / 100μlE20-74610-AF350$485 / 100μlE20-74610-AF405M$485 / 100μlE20-74610-AF488$485 / 100μlE20-74610-AF514$485 / 100μlE20-74610-AF532$485 / 100μlE20-74610-AF555$485 / 100μlE20-74610-AF568$485 / 100μlE20-74610-AF405S$485 / 100μlE20-74610-AF405L$485 / 100μlE20-74610-AF546$485 / 100μlE20-74610-AF594$485 / 100μlE20-74610-AF610$485 / 100μlE20-74610-AF635$485 / 100μlE20-74610-AF647$485 / 100μlE20-74610-AF680$485 / 100μlE20-74610-AF700$485 / 100μlE20-74610-AF750$485 / 100μlE20-74610-AF790$485 / 100μlE20-74610-APC$485 / 100μlE20-74610-PE$485 / 100μlE20-74610-Cy3$485 / 100μlE20-74610-Cy5$485 / 100μlE20-74610-Cy5.5$485 / 100μlE20-74610-Cy7$485 / 100μlE20-74610-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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