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TEL Polyclonal Antibody
Datasheet   

  • Catalog Number:

    E20-74600

  • Amount:

    100ul

  • Molecular Weight:

    53000(DA) Observed Band(KD)55

  • Price:

    225$

  • Purification:

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen:

    The antiserum was produced against synthesized peptide derived from human Tel. AA range:223-272

  • Source:

    Polyclonal, Rabbit

  • Western Blot analysis of HuvEc cells using TEL Polyclonal Antibody

  • Gene Name:

    ETV6

  • Dilution:

    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

  • Protein Name:

    Transcription factor ETV6

  • Human Gene Id:

    2120

  • Human Swiss Prot No:

    P41212

  • Mouse Swiss Prot No:

    P97360

  • Specificity:

    TEL Polyclonal Antibody detects endogenous levels of TEL protein.

  • Formulation:

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Concentration:

    1 mg/ml

  • Storage Stability:

    -20°C/1 year

  • Other Name:

    ETV6; TEL; TEL1; Transcription factor ETV6; ETS translocation variant 6; ETS-related protein Tel1; Tel

  • Background:

    ETS variant 6(ETV6) Homo sapiens This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008],

  • Function:

    disease:A chromosomal aberration involving ETV6 is a cause in many instances of chronic myeloproliferative disorder with eosinophilia (MPE) [MIM:131440]. Translocation t(5;12) with PDGFRB on chromosome 5 creating an ETV6-PDGFRB fusion protein.,disease:A chromosomal aberration involving ETV6 is a cause of acute lymphoblastic leukemia. Translocation t(9;12)(p13;p13) with PAX5.,disease:A chromosomal aberration involving ETV6 is a cause of myelodysplastic syndrome (MDS). Translocation t(1;12)(p36.1;p13) with MDS2.,disease:A chromosomal aberration involving ETV6 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;12)(q33;p13) with PDGFRB. It is characterized by abnormal clonal myeloid proliferation and by progression to acute myelogenous leukemia (AML).,disease:A chromosomal aberration involving ETV6 is found in a form of pre-B acute myeloid leukemia. Translocation

  • Subcellular Location:

    nucleus,nucleolus,cytoplasm,integral component of membrane,

  • Expression:

    Bone marrow,Testis,

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Catalog Number

  • Amount:100ul
  • Price:225$

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TEL Polyclonal Antibody | EnoGene Biotech Co. Ltd