TCF-4/12 Polyclonal Antibody

Name: TCF-4/12 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-74580
Price: 225 USD
Availability: InStock

E20-74580Cite ID: EN0054713Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight71308/72965 DaObserved Band:60 KD

Protein NameTranscription factor 4/12

Human Gene Id6925/6938

Human Swiss Prot NoP15884/Q99081

Mouse Gene Id21413/21406

Rat Gene Id84382/25720

Rat Swiss Prot NoQ62655/P51514

SpecificityTCF-4/12 Polyclonal Antibody detects endogenous levels of TCF-4/12 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameTCF4; BHLHB19; ITF2; SEF2; Transcription factor 4; TCF-4; Class B basic helix-loop-helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF-2; SL3-3 enhancer factor 2; SEF-2; TCF12; BHLHB20; HEB; HTF4; Transcription factor 12;

Functiondisease:Defects in TCF4 are a cause of Pitt-Hopkins syndrome (PTHS) [MIM:610954].,disease:Haploinsufficiency of TCF4 is a cause of Pitt-Hopkins syndrome (PTHS) [MIM:610954]. PTHS is a rare syndromic encephalopathy characterized by severe psychomotor delay, epilepsy, daily bouts of diurnal hyperventilation starting in infancy, mild postnatal growth retardation, postnatal microcephaly, and distinctive facial features. Since most hitherto reported cases have been sporadic, with males and females equally affected, PTHS is regarded as an autosomal dominant condition.,function:Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.,sequence caution:Incomplete and probable erro

Subcellular LocationNucleus .

ExpressionExpressed in adult heart, brain, placenta, skeletal muscle and to a lesser extent in the lung. In developing embryonic tissues, expression mostly occurs in the brain.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human TCF4/12. AA range:581-630

Gene NameTCF4/TCF12

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Backgroundtranscription factor 4(TCF4) Homo sapiens This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Jul 2016],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-74580-Conjugate. Price: $485 / Size: 100μl.

E20-74580-FITC$485 / 100μlE20-74580-Biotin$485 / 100μlE20-74580-HRP$485 / 100μlE20-74580-AP$485 / 100μlE20-74580-AF350$485 / 100μlE20-74580-AF405M$485 / 100μlE20-74580-AF488$485 / 100μlE20-74580-AF514$485 / 100μlE20-74580-AF532$485 / 100μlE20-74580-AF555$485 / 100μlE20-74580-AF568$485 / 100μlE20-74580-AF405S$485 / 100μlE20-74580-AF405L$485 / 100μlE20-74580-AF546$485 / 100μlE20-74580-AF594$485 / 100μlE20-74580-AF610$485 / 100μlE20-74580-AF635$485 / 100μlE20-74580-AF647$485 / 100μlE20-74580-AF680$485 / 100μlE20-74580-AF700$485 / 100μlE20-74580-AF750$485 / 100μlE20-74580-AF790$485 / 100μlE20-74580-APC$485 / 100μlE20-74580-PE$485 / 100μlE20-74580-Cy3$485 / 100μlE20-74580-Cy5$485 / 100μlE20-74580-Cy5.5$485 / 100μlE20-74580-Cy7$485 / 100μlE20-74580-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.