TCF-3 Polyclonal Antibody

Name: TCF-3 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-74579
Price: 225 USD
Availability: InStock

E20-74579Cite ID: EN0054712Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight(Da):67600

Protein NameTranscription factor E2-alpha

Human Gene Id6929

Human Swiss Prot NoP15923

Mouse Gene Id21423

Mouse Swiss Prot NoP15806

Rat Gene Id171046

Rat Swiss Prot NoP21677

SpecificityTCF-3 Polyclonal Antibody detects endogenous levels of TCF-3 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameTCF3; BHLHB21; E2A; ITF1; Transcription factor E2-alpha; Class B basic helix-loop-helix protein 21; bHLHb21; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; Kappa-E2-binding factor; Transcription facto

Observed Band(KD)68

Functiondisease:Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1; Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.,function:Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.,PTM:Phosphorylated following NGF stimulation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with ASH1 and TWIST2. Isoform E12 interacts with GRIPE and FIGLA (By similarity). Interacts with PTF1A and TGFB1I1.

Subcellular LocationNucleus .

ExpressionLymphoma,Muscle,PCR rescued clones,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human TCF3. AA range:571-620

Gene NameTCF3

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Backgroundtranscription factor 3(TCF3) Homo sapiens This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have bee

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-74579-Conjugate. Price: $485 / Size: 100μl.

E20-74579-FITC$485 / 100μlE20-74579-Biotin$485 / 100μlE20-74579-HRP$485 / 100μlE20-74579-AP$485 / 100μlE20-74579-AF350$485 / 100μlE20-74579-AF405M$485 / 100μlE20-74579-AF488$485 / 100μlE20-74579-AF514$485 / 100μlE20-74579-AF532$485 / 100μlE20-74579-AF555$485 / 100μlE20-74579-AF568$485 / 100μlE20-74579-AF405S$485 / 100μlE20-74579-AF405L$485 / 100μlE20-74579-AF546$485 / 100μlE20-74579-AF594$485 / 100μlE20-74579-AF610$485 / 100μlE20-74579-AF635$485 / 100μlE20-74579-AF647$485 / 100μlE20-74579-AF680$485 / 100μlE20-74579-AF700$485 / 100μlE20-74579-AF750$485 / 100μlE20-74579-AF790$485 / 100μlE20-74579-APC$485 / 100μlE20-74579-PE$485 / 100μlE20-74579-Cy3$485 / 100μlE20-74579-Cy5$485 / 100μlE20-74579-Cy5.5$485 / 100μlE20-74579-Cy7$485 / 100μlE20-74579-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.