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Cell Signal Transduction Research Antibodies
TBX1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight43133 DaObserved Band:43 KD
Protein NameT-box transcription factor TBX1
Human Gene Id6899
Human Swiss Prot NoO43435
Mouse Swiss Prot NoP70323
SpecificityTBX1 Polyclonal Antibody detects endogenous levels of TBX1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTBX1; T-box transcription factor TBX1; T-box protein 1; Testis-specific T-box protein
Functiondisease:Defects in TBX1 are a cause of conotruncal heart malformations (CTHM) [MIM:217095]. CTHM consist of cardiac outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis, and aortic arch anomalies.,disease:Defects in TBX1 are a cause of DiGeorge syndrome (DGS) [MIM:188400].,disease:Defects in TBX1 are a cause of velocardiofacial syndrome (VCFS) [MIM:192430].,disease:Haploinsufficiency of the TBX1 gene is responsible for most of the physical malformations present in DiGeorge syndrome (DGS) and velocardiofacial syndrome (VCFS) [MIM:188400, 192430]. DGS is characterized by the association of several malformations: hypoplastic thymus and parathyroid glands, congenital conotruncal cardiopathy, and a subtle but characteristic facial dysmorphology. VCFS is marked by the association of congenital conotruncal heart defect
Subcellular LocationNucleus .
ExpressionSkeletal muscle,Testis,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human TBX1. AA range:311-360
Gene NameTBX1
DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
BackgroundT-box 1(TBX1) Homo sapiens This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74564-Conjugate. Price: $485 / Size: 100μl.
E20-74564-FITC$485 / 100μlE20-74564-Biotin$485 / 100μlE20-74564-HRP$485 / 100μlE20-74564-AP$485 / 100μlE20-74564-AF350$485 / 100μlE20-74564-AF405M$485 / 100μlE20-74564-AF488$485 / 100μlE20-74564-AF514$485 / 100μlE20-74564-AF532$485 / 100μlE20-74564-AF555$485 / 100μlE20-74564-AF568$485 / 100μlE20-74564-AF405S$485 / 100μlE20-74564-AF405L$485 / 100μlE20-74564-AF546$485 / 100μlE20-74564-AF594$485 / 100μlE20-74564-AF610$485 / 100μlE20-74564-AF635$485 / 100μlE20-74564-AF647$485 / 100μlE20-74564-AF680$485 / 100μlE20-74564-AF700$485 / 100μlE20-74564-AF750$485 / 100μlE20-74564-AF790$485 / 100μlE20-74564-APC$485 / 100μlE20-74564-PE$485 / 100μlE20-74564-Cy3$485 / 100μlE20-74564-Cy5$485 / 100μlE20-74564-Cy5.5$485 / 100μlE20-74564-Cy7$485 / 100μlE20-74564-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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