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Cell Signal Transduction Research Antibodies
Tau Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight78746 DaObserved Band:50-85 KD
Protein NameMicrotubule-associated protein tau
Human Gene Id4137
Human Swiss Prot NoP10636
Mouse Gene Id17762
Mouse Swiss Prot NoP10637
Rat Swiss Prot NoP19332
SpecificityTau Polyclonal Antibody detects endogenous levels of Tau protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameMAPT; MAPTL; MTBT1; TAU; Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau
Functionalternative products:Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat,developmental stage:Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain.,disease:Defects in MAPT are a cause of corticobasal degeneration (CBD). It is marked by extrapyramidal signs and apraxia and can be associated with memory loss. Neuropathologic features may overlap Alzheimer disease, progressive supranuclear palsy, and Parkinson disease.,disease:Defects in MAPT are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17) [MIM:600274, 172700]; also called frontotemporal dementia (FTD) or historically termed Pick complex. This form
Subcellular LocationCytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Secreted . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .
ExpressionExpressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from human Tau. AA range:526-575
Gene NameMAPT
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Backgroundmicrotubule associated protein tau(MAPT) Homo sapiens This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-74553-Conjugate. Price: $485 / Size: 100μl.
E20-74553-FITC$485 / 100μlE20-74553-Biotin$485 / 100μlE20-74553-HRP$485 / 100μlE20-74553-AP$485 / 100μlE20-74553-AF350$485 / 100μlE20-74553-AF405M$485 / 100μlE20-74553-AF488$485 / 100μlE20-74553-AF514$485 / 100μlE20-74553-AF532$485 / 100μlE20-74553-AF555$485 / 100μlE20-74553-AF568$485 / 100μlE20-74553-AF405S$485 / 100μlE20-74553-AF405L$485 / 100μlE20-74553-AF546$485 / 100μlE20-74553-AF594$485 / 100μlE20-74553-AF610$485 / 100μlE20-74553-AF635$485 / 100μlE20-74553-AF647$485 / 100μlE20-74553-AF680$485 / 100μlE20-74553-AF700$485 / 100μlE20-74553-AF750$485 / 100μlE20-74553-AF790$485 / 100μlE20-74553-APC$485 / 100μlE20-74553-PE$485 / 100μlE20-74553-Cy3$485 / 100μlE20-74553-Cy5$485 / 100μlE20-74553-Cy5.5$485 / 100μlE20-74553-Cy7$485 / 100μlE20-74553-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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