TANK Polyclonal Antibody

Name: TANK Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-74540
Price: 225 USD
Availability: InStock

E20-74540Cite ID: EN0054673Datasheet COA MSDS

ReactivityHuman;Mouse;Rat

ApplicationsWB;IHC-p;IF/ICC;ELISA

SourcePolyclonal, Rabbit,IgG

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight47816Da

Protein NameTRAF family member-associated NF-kappa-B activator

Human Gene Id10010

Human Swiss Prot NoQ92844

Mouse Gene Id21353

Mouse Swiss Prot NoP70347

SpecificityTANK Polyclonal Antibody detects endogenous levels of TANK protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameTANK; ITRAF; TRAF2; TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein; I-TRAF

Observed Band(KD)48

Functionfunction:Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity.,PTM:Phosphorylated by IKBKE.,similarity:Contains 1 C2H2-type zinc finger.,subunit:Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary comple

Subcellular LocationCytoplasm.

ExpressionUbiquitous.

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from human TANK. AA range:171-220

Gene NameTANK

DilutionWestern Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

BackgroundThe TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-74540-Conjugate. Price: $485 / Size: 100μl.

E20-74540-FITC$485 / 100μlE20-74540-Biotin$485 / 100μlE20-74540-HRP$485 / 100μlE20-74540-AP$485 / 100μlE20-74540-AF350$485 / 100μlE20-74540-AF405M$485 / 100μlE20-74540-AF488$485 / 100μlE20-74540-AF514$485 / 100μlE20-74540-AF532$485 / 100μlE20-74540-AF555$485 / 100μlE20-74540-AF568$485 / 100μlE20-74540-AF405S$485 / 100μlE20-74540-AF405L$485 / 100μlE20-74540-AF546$485 / 100μlE20-74540-AF594$485 / 100μlE20-74540-AF610$485 / 100μlE20-74540-AF635$485 / 100μlE20-74540-AF647$485 / 100μlE20-74540-AF680$485 / 100μlE20-74540-AF700$485 / 100μlE20-74540-AF750$485 / 100μlE20-74540-AF790$485 / 100μlE20-74540-APC$485 / 100μlE20-74540-PE$485 / 100μlE20-74540-Cy3$485 / 100μlE20-74540-Cy5$485 / 100μlE20-74540-Cy5.5$485 / 100μlE20-74540-Cy7$485 / 100μlE20-74540-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.