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T2R1 Polyclonal Antibody
Datasheet
Catalog Number:
E20-74503Amount:
100ulPrice:
225$Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Immunogen:
The antiserum was produced against synthesized peptide derived from human TAS2R1. AA range:6-55Source:
Polyclonal, RabbitGene Name:
TAS2R1Dilution:
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
- Western blot analysis of lysates from MCF-7 cells, using TAS2R1 Antibody. The lane on the right is blocked with the synthesized peptide.
Background:
taste 2 receptor member 1(TAS2R1) Homo sapiens This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008],Protein Name:
Taste receptor type 2 member 1Human Gene Id:
50834Human Swiss Prot No:
Q9NYW7Specificity:
T2R1 Polyclonal Antibody detects endogenous levels of T2R1 protein.Formulation:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.Concentration:
1 mg/mlStorage Stability:
-20°C/1 yearOther Name:
TAS2R1; Taste receptor type 2 member 1; T2R1; Taste receptor family B member 7; TRB7MolecularWeight(Da):
34333Observed Band(KD):
33Function:
function:Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.,miscellaneous:Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.,similarity:Belongs to the G-protein coupled receptor T2R family.,tissue specificity:Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells.,Subcellular Location:
plasma membrane,integral component of membrane,Expression:
Brain cortex,G-protein coupled receptors,
- Western blot analysis of the lysates from K562 cells using TAS2R1 antibody.
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